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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ncoa6
nuclear receptor coactivator 6
MGI:1929915
110 phenotypes from 9 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ncoa6em1(IMPC)J/Ncoa6+
C57BL/6NJ-Ncoa6em1(IMPC)J/J 		abnormal retina morphology J:211773
decreased total body fat amount J:211773
Ncoa6em1(IMPC)J/Ncoa6em1(IMPC)J
C57BL/6NJ-Ncoa6em1(IMPC)J/J 		preweaning lethality, incomplete penetrance J:211773
Ncoa6tm1.1Jkr/Ncoa6tm1.1Jkr
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal blood vessel morphology J:81217
abnormal brain development J:81217
abnormal digit morphology J:81217
abnormal embryonic hematopoiesis J:81217
abnormal epicardium morphology J:81217
abnormal eye pigmentation J:81217
abnormal fetal cardiomyocyte morphology J:81217
abnormal fetal cardiomyocyte proliferation J:81217
abnormal heart morphology J:81217
abnormal heart ventricle morphology J:81217
abnormal liver bud morphology J:81217
abnormal liver morphology J:81217
abnormal myocardium layer morphology J:81217
abnormal palatal shelf fusion at midline J:81217
abnormal placenta morphology J:81217
abnormal placenta vasculature J:81217
abnormal placental labyrinth vasculature morphology J:81217
abnormal spongiotrophoblast layer morphology J:81217
abnormal trophoblast layer morphology J:81217
abnormal vitelline vasculature morphology J:81217
decreased embryo size J:81217
decreased erythroid progenitor cell number J:81217
decreased hepatocyte number J:81217
detached epicardium J:81217
dilated vasculature J:81217
embryonic growth retardation J:81217
embryonic lethality during organogenesis, complete penetrance J:81217
increased hepatocyte apoptosis J:81217
pallor J:81217
small liver J:81217
thin myocardium compact layer J:81217
trabecula carnea hypoplasia J:81217
Ncoa6tm1Hhs/Ncoa6+
129S6/SvEvTac-Ncoa6tm1Hhs 		decreased birth body size J:91083
decreased birth weight J:91083
decreased hair follicle number J:91083
decreased litter size J:91083
delayed wound healing J:91083
female infertility J:91083
impaired wound healing J:91083
increased sebaceous gland number J:91083
neonatal lethality, incomplete penetrance J:91083
prenatal lethality, incomplete penetrance J:91083
reduced female fertility J:91083
reduced male fertility J:91083
thick epidermis J:91083
Ncoa6tm1Hhs/Ncoa6+
involves: 129S6/SvEvTac * C57BL/6 		decreased birth body size J:91083
decreased hair follicle number J:91083
delayed wound healing J:91083
impaired wound healing J:91083
increased sebaceous gland number J:91083
normal reproductive system phenotype J:91083
thick epidermis J:91083
Ncoa6tm1Hhs/Ncoa6tm1Hhs
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6) 		abnormal brain development J:91083
abnormal heart development J:91083
abnormal liver development J:91083
abnormal vascular development J:91083
decreased embryo size J:91083
decreased fibroblast proliferation J:91083
embryonic lethality, complete penetrance J:91083
hindlimb oligodactyly J:91083
impaired placental function J:91083
increased fibroblast apoptosis J:91083
Ncoa6tm1Hhs/Ncoa6tm1Hhs
involves: 129S6/SvEvTac 		abnormal cell physiology J:116064
Ncoa6tm1Jkr/Ncoa6+
Tg(Myh6-cre)2182Mds/0
involves: 129P2/OlaHsd * FVB/N 		abnormal heart echocardiography feature J:269856
decreased cardiac muscle contractility J:269856
dilated cardiomyopathy J:269856
Ncoa6tm1Jkr/Ncoa6tm1Jkr
Tg(MMTV-cre)FMam/?
involves: 129P2/OlaHsd * FVB 		abnormal branching of the mammary ductal tree J:121207
abnormal mammary duct terminal end bud morphology J:121207
abnormal mammary gland development J:121207
abnormal mammary gland growth during lactation J:121207
abnormal mammary gland growth during pregnancy J:121207
hypolactation J:121207
Ncoa6tm1Jkr/Ncoa6tm1Jkr
Tg(Myh6-cre)2182Mds/0
involves: 129P2/OlaHsd * FVB/N 		abnormal atrial thrombosis J:269856
abnormal heart echocardiography feature J:269856
abnormal heart morphology J:269856
abnormal lipid level J:269856
abnormal sarcomere morphology J:269856
cardiac hypertrophy J:269856
decreased cardiac muscle contractility J:269856
decreased mitochondrial number J:269856
dilated cardiomyopathy J:269856
dilated heart J:269856
dilated heart left ventricle J:269856
increased heart weight J:269856
premature death J:269856
Ncoa6tm1Jxu/Ncoa6tm1Jxu
involves: 129S6/SvEvTac * C57BL/6 		abnormal placenta development J:80175
abnormal syncytiotrophoblast morphology J:80175
abnormal trophoblast giant cell morphology J:80175
absent placental labyrinth J:80175
decreased embryo size J:80175
decreased fetal cardiomyocyte proliferation J:80175
decreased spongiotrophoblast cell number J:80175
disorganized myocardium J:80175
embryonic growth retardation J:80175
embryonic lethality during organogenesis, incomplete penetrance J:80175
heart hypoplasia J:80175
increased trophoblast giant cell number J:80175
pericardial effusion J:80175
thin ventricular wall J:80175
trabecula carnea hypoplasia J:80175
Ncoa6tm1Pera/Ncoa6tm1Pera
involves: 129X1/SvJ * C57BL/6 		abnormal hypothalamus morphology J:81818
abnormal placenta morphology J:81818
abnormal placenta vasculature J:81818
abnormal placental labyrinth vasculature morphology J:81818
absent olfactory bulb J:81818
decreased neuron number J:81818
decreased spongiotrophoblast size J:81818
delayed brain development J:81818
dilated third ventricle J:81818
disorganized myocardium J:81818
lethality throughout fetal growth and development, complete penetrance J:81818
small thalamus J:81818
thin myocardium J:81818
thin ventricular wall J:81818
trabecula carnea hypoplasia J:81818
Ncoa6tm2Jxu/Ncoa6tm2Jxu
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		abnormal bile salt homeostasis J:129067
abnormal circulating triglyceride level J:129067
abnormal feces composition J:129067
abnormal hepatocyte morphology J:129067
abnormal lipid homeostasis J:129067
abnormal liver morphology J:129067
increased circulating cholesterol level J:129067
increased liver weight J:129067
normal reproductive system phenotype J:129067
Ncoa6tm3.1Jxu/Ncoa6tm3.1Jxu
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		abnormal lens morphology J:165054
cataract J:165054
small lens J:165054
Ncoa6tm3Jxu/Ncoa6tm3.1Jxu
Tg(Pax6-cre,GFP)1Pgr/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		abnormal lens morphology J:165054
cataract J:165054
small lens J:165054
Ncoa6tm3Jxu/Ncoa6tm3Jxu
Pgrtm2(cre)Lyd/Pgr+
involves: 129/Sv * C57BL/6 * SJL 		abnormal decidualization J:189065
abnormal luminal closure J:189065
abnormal uterine receptivity J:189065
female infertility J:189065
Ncoa6tm3Jxu/Ncoa6tm3Jxu
Tg(Pax6-cre,GFP)1Pgr/0
involves: 129S6/SvEvTac * FVB/N 		cataract J:165054
small lens J:165054
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory