Klf15 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Klf15
Kruppel-like transcription factor 15
MGI:1929988

41 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Klf15^hlb444/? C57BL/6J-Klf15^hlb444/J	increased circulating triglyceride level	J:77944
Klf15^tm1Jain/Klf15^tm1Jain B6.129X1-Klf15^tm1Jain	abdominal aorta aneurysm	J:167880
	abnormal angiogenesis	J:167880
	abnormal aorta morphology	J:167880
	abnormal aorta tunica adventitia morphology	J:167880
	abnormal aorta tunica media morphology	J:167880
	abnormal circulating amino acid level	J:129763
	abnormal enzyme/coenzyme activity	J:129763
	abnormal gluconeogenesis	J:129763
	abnormal hepatocyte physiology	J:129763
	abnormal metabolism	J:129763
	aortic hypertrophy	J:167880
	cardiomyopathy	J:167880
	decreased circulating glucose level	J:129763
	decreased circulating lactate level	J:129763
	decreased heart left ventricle muscle contractility	J:121109
	decreased liver glycogen level	J:129763
	decreased total body fat amount	J:129763
	dilated aorta	J:167880
	dilated heart	J:121109
	dilated heart left ventricle	J:121109
	enlarged heart	J:167880
	normal growth/size/body region phenotype	J:129763
	heart left ventricle hypertrophy	J:167880
	normal homeostasis/metabolism phenotype	J:129763
	hypoglycemia	J:129763
	improved glucose tolerance	J:129763
	increased circulating glucagon level	J:129763
	increased circulating ketone body level	J:129763
	increased glycerol level	J:129763
	increased lean body mass	J:129763
	increased myocardial fiber size	J:121109
	increased response of heart to induced stress	J:121109, J:167880
	increased susceptibility to induced aneurysm formation	J:167880
	increased susceptibility to induced morbidity/mortality	J:121109
	ketoaciduria	J:129763
	thoracic aorta aneurysm	J:167880
Klf15^tm1Jain/Klf15^tm1Jain involves: 129X1/SvJ	blood vessel inflammation	J:203920
	increased macrophage cell number	J:203920
	increased susceptibility to atherosclerosis	J:203920
Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0 involves: FVB/N	normal mortality/aging	J:203920

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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