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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Trpm7
transient receptor potential cation channel, subfamily M, member 7
MGI:1929996
54 phenotypes from 6 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Trpm7Gt(XC765)Byg/Trpm7Gt(XC765)Byg
involves: 129P2/OlaHsd * C57BL/6J 		embryonic lethality between implantation and somite formation, complete penetrance J:140630
Trpm7tm1.1Clph/Trpm7tm1.1Clph
involves: 129S4/SvJae 		embryonic lethality, complete penetrance J:140630
Trpm7tm1.1Mkma/Trpm7tm1.1Mkma
B6.129-Trpm7tm1.1Mkma 		no abnormal phenotype detected J:221252
Trpm7tm1Agry/Trpm7+
involves: 129 		abnormal channel response J:205665
abnormal digestion J:205665
abnormal magnesium ion homeostasis J:205665
decreased circulating magnesium level J:205665
decreased erythrocyte magnesium level J:205665
decreased urine magnesium level J:205665
increased susceptibility to induced morbidity/mortality J:205665
increased susceptibility to type IV hypersensitivity reaction J:205665
limb grasping J:205665
seizures J:205665
tremors J:205665
Trpm7tm1Agry/Trpm7tm1Agry
involves: 129 		abnormal cell physiology J:205665
decreased embryo size J:205665
embryonic growth arrest J:205665
prenatal lethality, complete penetrance J:205665
Trpm7tm1b(KOMP)Wtsi/Trpm7+
C57BL/6N-Trpm7tm1b(KOMP)Wtsi/H 		increased circulating alkaline phosphatase level J:211773
thrombocytosis J:211773
Trpm7tm1b(KOMP)Wtsi/Trpm7tm1b(KOMP)Wtsi
C57BL/6N-Trpm7tm1b(KOMP)Wtsi/H 		embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Trpm7tm1Clph/Trpm7tm1.1Clph
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJae * C57BL/6 * CBA 		embryonic lethality, complete penetrance J:140630
Trpm7tm1Clph/Trpm7tm1.1Clph
Tg(Gata1-cre)1Sho/0
involves: 129S4/SvJae * CD-1 		embryonic lethality, complete penetrance J:140630
Trpm7tm1Clph/Trpm7tm1.1Clph
Tg(Lck-cre)548Jxm/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal T cell differentiation J:140630
abnormal T cell physiology J:140630
abnormal thymus cell ratio J:140630
abnormal thymus corticomedullary boundary morphology J:140630
abnormal thymus medulla morphology J:140630
abnormal thymus morphology J:140630
decreased T cell number J:140630
decreased thymocyte number J:140630
Trpm7tm1Clph/Trpm7tm1Clph
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal developmental patterning J:181963
abnormal embryo morphology J:181963
embryonic lethality, complete penetrance J:181963
no abnormal phenotype detected J:181963
Trpm7tm1Clph/Trpm7tm1Clph
Tg(Hoxb7-cre)5526Cmb/0
involves: 129S4/SvJae 		normal renal/urinary system phenotype J:181963
Trpm7tm1Clph/Trpm7tm1Clph
Tg(Nes-cre)1Kln/0
involves: 129S4/SvJae * C57BL/6 * SJL 		no abnormal phenotype detected J:181963
Trpm7tm1Clph/Trpm7tm1Clph
Tg(Pax3-cre)1Joe/0
involves: 129S4/SvJae * C57BL/6 * SJL 		abnormal comma shaped body morphology J:181963
abnormal hair follicle melanocyte morphology J:181963
abnormal kidney development J:181963
abnormal nephron morphogenesis J:181963
abnormal renal tubule morphology J:181963
abnormal rostrocaudal coat patterning J:181963
abnormal S-shaped body morphology J:181963
absent hair follicle melanin granules J:181963
decreased melanocyte number J:181963
decreased renal glomerulus number J:181963
decreased sensory neuron number J:181963
dilated renal tubule J:181963
hindlimb paralysis J:181963
hypopigmentation J:181963
impaired limb coordination J:181963
kidney cortex cyst J:181963
kidney cyst J:181963
kidney failure J:181963
paresis J:181963
small dorsal root ganglion J:181963
small kidney J:181963
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11/12/2024
MGI 6.24 		The Jackson Laboratory