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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Shank3
SH3 and multiple ankyrin repeat domains 3
MGI:1930016
127 phenotypes from 18 alleles in 22 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Shank3em1(IMPC)H/Shank3em1(IMPC)H
C57BL/6NTac-Shank3em1(IMPC)H/H 		decreased circulating calcium level J:211773
Shank3em1Hzo/Shank3em1Hzo
involves: C57BL/6J 		abnormal allogrooming behavior J:305052
abnormal miniature excitatory postsynaptic currents J:305052
abnormal social/conspecific interaction behavior J:305052
decreased dendritic spine density J:305052
decreased vocalization J:305052
Shank3tm1.1Cya/Shank3+
B6.Cg-Shank3tm1.1Cya 		abnormal vocalization J:281328
normal behavior/neurological phenotype J:281328
decreased stereotypic behavior J:281328
increased anxiety-related response J:281328
increased grooming behavior J:281328
Shank3tm1.1Cya/Shank3tm1.1Cya
B6.Cg-Shank3tm1.1Cya 		abnormal brain wave pattern J:281328
abnormal nervous system electrophysiology J:281328
abnormal neuron physiology J:281328
normal behavior/neurological phenotype J:281328
decreased stereotypic behavior J:281328
decreased susceptibility to pharmacologically induced seizures J:281328
normal growth/size/body region phenotype J:281328
increased anxiety-related response J:281328
increased grooming behavior J:281328
increased miniature inhibitory postsynaptic current frequency J:281328
normal mortality/aging J:281328
Shank3tm1.1Geno/Shank3tm1.1Geno
involves: C57BL/6 		abnormal response to novel object J:293942
abnormal response to novelty J:293942
skin lesions J:186719
Shank3tm1.1Pfw/Shank3+
B6.129S6-Shank3tm1.1Pfw 		abnormal glutamate-mediated receptor currents J:198768
abnormal long-term depression J:198768
abnormal social investigation J:198768
abnormal social/conspecific interaction behavior J:198768
abnormal vocalization J:198768
normal behavior/neurological phenotype J:198768
decreased startle reflex J:198768
decreased synaptic depression J:198768
increased aggression towards mice J:198768
induced hyperactivity J:198768
reduced long-term potentiation J:198768
reduced NMDA-mediated synaptic currents J:198768
Shank3tm1.1Pfw/Shank3tm1.1Pfw
B6.129S6-Shank3tm1.1Pfw 		abnormal excitatory postsynaptic currents J:204162
abnormal glutamate-mediated receptor currents J:204162
abnormal innate avoidance response J:204162
abnormal miniature excitatory postsynaptic currents J:204162
abnormal motor coordination/balance J:204162
abnormal response to novel object J:204162
abnormal response to novelty J:204162
abnormal social investigation J:204162
abnormal spatial reference memory J:204162
normal behavior/neurological phenotype J:204162
decreased body weight J:204162
decreased exploration in new environment J:204162
decreased thermal nociceptive threshold J:204162
impaired coordination J:204162
impaired spatial learning J:204162
increased grooming behavior J:204162
normal nervous system phenotype J:204162
photophobia J:204162
reduced long-term potentiation J:204162
Shank3tm1.2Bux/Shank3+
129S6.B6(Cg)-Shank3tm1.2Bux 		decreased anxiety-related response J:206790
impaired coordination J:206790
increased locomotor activity J:206790
increased thigmotaxis J:206790
Shank3tm1.2Bux/Shank3+
B6N.Cg-Shank3tm1.2Bux 		decreased locomotor activity J:206790
Shank3tm1.2Bux/Shank3+
C57BL/6-Shank3tm1.2Bux 		abnormal excitatory postsynaptic potential J:175320
abnormal miniature excitatory postsynaptic currents J:175320
abnormal neuron physiology J:175320
abnormal social investigation J:175320
decreased paired-pulse ratio J:175320
decreased vocalization J:175320
reduced long-term potentiation J:175320
Shank3tm1.2Bux/Shank3tm1.2Bux
129S6.B6(Cg)-Shank3tm1.2Bux 		abnormal conditioned emotional response J:206790
normal behavior/neurological phenotype J:206790
decreased anxiety-related response J:206790
decreased body weight J:206790
decreased grip strength J:206790
increased locomotor activity J:206790
lethality, incomplete penetrance J:206790
Shank3tm1.2Bux/Shank3tm1.2Bux
B6N.Cg-Shank3tm1.2Bux 		abnormal response to novel object J:206790
decreased anxiety-related response J:206790
decreased body weight J:206790
decreased locomotor activity J:206790
decreased vertical activity J:206790
hyporesponsive to tactile stimuli J:206790
impaired coordination J:206790
lethality, incomplete penetrance J:206790
Shank3tm1.2Bux/Shank3tm1.2Bux
FVB.B6(Cg)-Shank3tm1.2Bux 		abnormal response to novel object J:206790
normal behavior/neurological phenotype J:206790
decreased anxiety-related response J:206790
decreased body weight J:206790
increased vertical activity J:206790
lethality, incomplete penetrance J:206790
Shank3tm1Cmpl/Shank3tm1Cmpl
B6J.129S6-Shank3tm1Cmpl 		abnormal CNS synaptic transmission J:224381
abnormal excitatory postsynaptic potential J:224381
abnormal long-term depression J:224381
abnormal miniature excitatory postsynaptic currents J:224381
abnormal motor learning J:224381
abnormal response to novel object J:224381
decreased body weight J:224381
decreased exploration in new environment J:224381
decreased post-tetanic potentiation J:224381
impaired coordination J:224381
impaired spatial learning J:224381
impaired synaptic plasticity J:224381
Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
involves: C57BL/6N 		abnormal CNS synaptic transmission J:233405
abnormal excitatory postsynaptic potential J:233405
abnormal miniature inhibitory postsynaptic current frequency J:233405
abnormal response to novelty J:233405
normal behavior/neurological phenotype J:233405
impaired spatial learning J:233405
increased vertical activity J:233405
Shank3tm1Gfng/Shank3tm1Gfng
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal behavior/neurological phenotype J:171113
normal integument phenotype J:171113
Shank3tm1Yhj/Shank3tm1Yhj
B6.129S7-Shank3tm1Yhj 		abnormal dendritic spine morphology J:173402
abnormal gait J:173402
abnormal long-term object recognition memory J:173402
abnormal motor capabilities/coordination/movement J:173402
abnormal motor learning J:173402
abnormal object recognition memory J:173402
abnormal social investigation J:173402
abnormal spatial learning J:173402
abnormal vocalization J:173402
normal behavior/neurological phenotype J:173402
decreased locomotor activity J:173402
decreased post-tetanic potentiation J:173402
decreased vertical activity J:173402
impaired coordination J:173402
impaired righting response J:173402
impaired synaptic plasticity J:173402
increased body weight J:173402
increased grooming behavior J:173402
increased stereotypic behavior J:173402
normal nervous system phenotype J:173402
reduced long-term potentiation J:173402
normal taste/olfaction phenotype J:173402
Shank3tm2.1Bux/Shank3+
B6(Cg)-Shank3tm2.1Bux 		abnormal nest building behavior J:270363
decreased locomotor activity J:270363
decreased startle reflex J:270363
decreased vocalization J:270363
impaired coordination J:270363
premature suckling reflex loss J:270363
Shank3tm2.1Bux/Shank3tm2.1Bux
B6(Cg)-Shank3tm2.1Bux 		abnormal habituation to a novel odor J:270363
abnormal impulsive behavior control J:270363
abnormal locomotor activation J:270363
abnormal nest building behavior J:270363
abnormal reflex J:270363
abnormal response to novel object J:270363
abnormal righting response J:270363
abnormal sexual interaction J:270363
circling J:270363
decreased locomotor activity J:270363
decreased prepulse inhibition J:270363
decreased startle reflex J:270363
decreased vertical activity J:270363
decreased vocalization J:270363
enhanced cued conditioning behavior J:270363
hyperactivity J:270363
impaired contextual conditioning behavior J:270363
impaired coordination J:270363
impaired spatial learning J:270363
increased anxiety-related response J:270363
increased fear-related response J:270363
increased grooming behavior J:270363
long stride length J:270363
neonatal lethality, incomplete penetrance J:270363
postnatal growth retardation J:270363
premature death J:270363
premature suckling reflex loss J:270363
weakness J:270363
Shank3tm2.2Yhj/Shank3tm2.2Yhj
B6.129S7(C)-Shank3tm2.2Yhj 		abnormal autopod morphology J:235641
abnormal basal ganglion morphology J:235641
abnormal behavior J:235641
abnormal brain commissure morphology J:235641
abnormal brain internal capsule morphology J:235641
abnormal brain white matter morphology J:235641
abnormal cerebellar peduncle morphology J:235641
abnormal cingulum morphology J:235641
abnormal dendritic spine morphology J:235641
abnormal ear development J:235641
abnormal nervous system electrophysiology J:235641
abnormal odor adaptation J:235641
abnormal olfactory lobe morphology J:235641
abnormal response to new environment J:235641
abnormal single cell response J:235641
abnormal social investigation J:235641
abnormal social/conspecific interaction behavior J:235641
abnormal spinal cord commissure morphology J:235641
abnormal synapse morphology J:235641
decreased amygdala size J:235641
decreased excitatory postsynaptic current frequency J:235641
decreased locomotor activity J:235641
decreased vocalization J:235641
enhanced contextual conditioning behavior J:235641
impaired coordination J:235641
impaired learning J:235641
impaired spatial learning J:235641
increased anxiety-related response J:235641
increased grooming behavior J:235641
increased startle reflex J:235641
normal nervous system phenotype J:235641
reduced long-term depression J:235641
skin lesions J:235641
small hippocampus J:235641
thalamus hyperplasia J:235641
Shank3tm2.2Yhj/Shank3tm2.2Yhj
involves: 129S7/SvEvBrd * C57BL/6J 		increased grooming behavior J:235641
skin lesions J:235641
Shank3tm2Cmpl/Shank3+
B6.129S6-Shank3tm2Cmpl 		abnormal motor learning J:289874
abnormal response to social novelty J:289874
abnormal social investigation J:289874
abnormal social recognition J:289874
decreased anxiety-related response J:289874
decreased vertical activity J:289874
impaired coordination J:289874
increased grooming behavior J:289874
reduced long-term potentiation J:289874
Shank3tm2Cmpl/Shank3tm2Cmpl
B6.129S6-Shank3tm2Cmpl 		abnormal response to social novelty J:289874
abnormal social investigation J:289874
abnormal social recognition J:289874
abnormal spatial reference memory J:289874
abnormal synaptic transmission J:289874
decreased anxiety-related response J:289874
decreased vertical activity J:289874
impaired coordination J:289874
impaired spatial learning J:289874
impaired synaptic plasticity J:289874
increased grooming behavior J:289874
reduced long-term potentiation J:289874
Shank3tm2Gfng/Shank3+
B6.129-Shank3tm2Gfng/J 		impaired discrimination learning J:243083
Shank3tm2Gfng/Shank3tm2Gfng
B6.129-Shank3tm2Gfng/J 		abnormal learning/memory/conditioning J:243083
decreased locomotor activity J:243083
Shank3tm2Gfng/Shank3tm2Gfng
involves: 129S1/Sv * 129X1/SvJ 		abnormal dendritic mushroom spine morphology J:305052
abnormal dendritic thin spine morphology J:305052
abnormal miniature excitatory postsynaptic currents J:305052
abnormal postsynaptic density morphology J:305052
Shank3tm2Gfng/Shank3tm2Gfng
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal medium spiny neuron morphology J:171113
abnormal miniature excitatory postsynaptic currents J:171113
abnormal postsynaptic density morphology J:171113
abnormal striatum morphology J:171113
normal behavior/neurological phenotype J:171113
decreased vertical activity J:171113
environmentally induced seizures J:171113
increased anxiety-related response J:171113
increased grooming behavior J:171113
skin lesions J:171113
social withdrawal J:171113
Shank3tm3.1Gfng/Shank3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal allogrooming behavior J:230887
abnormal miniature excitatory postsynaptic currents J:230887
decreased exploration in new environment J:230887
increased anxiety-related response J:230887
Shank3tm3.1Gfng/Shank3tm3.1Gfng
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal dendritic spine morphology J:230887
abnormal miniature excitatory postsynaptic currents J:230887
abnormal motor learning J:230887
abnormal paired-pulse inhibition J:230887
abnormal social investigation J:230887
abnormal social/conspecific interaction behavior J:230887
abnormal startle reflex J:230887
decreased excitatory postsynaptic current amplitude J:230887
decreased exploration in new environment J:230887
decreased locomotor activity J:230887
impaired coordination J:230887
increased aggression towards mice J:230887
increased anxiety-related response J:230887
increased grooming behavior J:230887
reduced NMDA-mediated synaptic currents J:230887
Shank3tm3.2Cmpl/Shank3+
B6.129S6(Cg)-Shank3tm3.2Cmpl 		abnormal object recognition memory J:289884
abnormal synaptic transmission J:289884
excessive vocalization J:289884
impaired spatial learning J:289884
increased grooming behavior J:289884
Shank3tm3.2Cmpl/Shank3tm3.2Cmpl
B6.129S6(Cg)-Shank3tm3.2Cmpl 		abnormal object recognition memory J:289884
abnormal social investigation J:289884
abnormal synaptic transmission J:289884
normal behavior/neurological phenotype J:289884
excessive vocalization J:289884
impaired spatial learning J:289884
impaired synaptic plasticity J:289884
increased grooming behavior J:289884
increased thigmotaxis J:289884
reduced long-term potentiation J:289884
Shank3tm4.1Gfng/Shank3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal dendritic spine morphology J:230887
abnormal miniature excitatory postsynaptic currents J:230887
abnormal social investigation J:230887
increased anxiety-related response J:230887
Shank3tm4.1Gfng/Shank3tm4.1Gfng
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal dendritic spine morphology J:230887
abnormal miniature excitatory postsynaptic currents J:230887
abnormal motor learning J:230887
abnormal paired-pulse inhibition J:230887
abnormal social investigation J:230887
abnormal startle reflex J:230887
decreased excitatory postsynaptic current amplitude J:230887
decreased exploration in new environment J:230887
decreased locomotor activity J:230887
impaired coordination J:230887
increased aggression towards mice J:230887
increased anxiety-related response J:230887
increased grooming behavior J:230887
reduced NMDA-mediated synaptic currents J:230887
Shank3tm5.1Gfng/Shank3tm5.1Gfng
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J 		decreased excitatory postsynaptic current amplitude J:229668
decreased exploration in new environment J:229668
impaired coordination J:229668
increased anxiety-related response J:229668
increased grooming behavior J:229668
Shank3tm5.1Gfng/Shank3tm5.1Gfng
Tg(CAG-cre/Esr1*)1Lbe/0
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J 		abnormal dendritic spine morphology J:229668
abnormal medium spiny neuron morphology J:229668
abnormal miniature excitatory postsynaptic currents J:229668
abnormal social investigation J:229668
decreased body weight J:229668
decreased excitatory postsynaptic current amplitude J:229668
decreased exploration in new environment J:229668
decreased vertical activity J:229668
impaired coordination J:229668
increased anxiety-related response J:229668
increased grooming behavior J:229668
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory