Rps6ka4 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rps6ka4
ribosomal protein S6 kinase, polypeptide 4
MGI:1930076

17 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Il10^tm1Cgn/Il10^tm1Cgn Rps6ka4^tm1Jsca/Rps6ka4^tm1Jsca Rps6ka5^tm1Jsca/Rps6ka5^tm1Jsca B6.Cg-Il10^tm1Cgn Rps6ka5^tm1Jsca Rps6ka4^tm1Jsca	decreased interleukin-10 secretion	J:139576
	increased interleukin-6 secretion	J:139576
	increased interleukin-12a secretion	J:139576
	increased interleukin-12b secretion	J:139576
	increased tumor necrosis factor secretion	J:139576
Rps6ka4^tm1Jsca/Rps6ka4^tm1Jsca Rps6ka5^tm1Jsca/Rps6ka5^tm1Jsca B6.Cg-Rps6ka5^tm1Jsca Rps6ka4^tm1Jsca	abnormal cytokine level	J:139576
	abnormal cytokine secretion	J:139576
	decreased circulating interleukin-10 level	J:139576
	decreased interleukin-10 secretion	J:139576
	increased circulating interleukin-6 level	J:139576
	increased circulating interleukin-12a level	J:139576
	increased circulating interleukin-12b level	J:139576
	increased circulating tumor necrosis factor level	J:139576
	increased interleukin-6 secretion	J:139576
	increased interleukin-12a secretion	J:139576
	increased interleukin-12b secretion	J:139576
	increased susceptibility to endotoxin shock	J:139576
	increased susceptibility to induced morbidity/mortality	J:139576
	increased tumor necrosis factor secretion	J:139576
	skin inflammation	J:139576
Rps6ka4^tm1Jsca/Rps6ka4^tm1Jsca Rps6ka5^tm1Jsca/Rps6ka5^tm1Jsca Not Specified	decreased T cell proliferation	J:124301
	spleen hypoplasia	J:124301

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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