Pdcd1lg2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pdcd1lg2
programmed cell death 1 ligand 2
MGI:1930125

21 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pdcd1lg2^tm1.1Lex/Pdcd1lg2^tm1.1Lex involves: 129S5/SvEvBrd	decreased CD8-positive, alpha-beta T cell number	J:126829
Pdcd1lg2^tm1Dmp/Pdcd1lg2^tm1Dmp C.129-Pdcd1lg2^tm1Dmp	abnormal cytokine secretion	J:99212
	abnormal cytotoxic T cell physiology	J:99212
	decreased IgG2a level	J:99212
	decreased T cell proliferation	J:99212
	increased susceptibility to induced morbidity/mortality	J:99212
	increased tumor growth/size	J:99212
Pdcd1lg2^tm1Dmp/Pdcd1lg2^tm1Dmp involves: 129X1/SvJ * 129S1/Sv * C57BL/6	abnormal dendritic cell antigen presentation	J:84457
Pdcd1lg2^tm1Shr/Pdcd1lg2^tm1Shr involves: 129/Sv * 129S4/SvJae	increased IgG2a level	J:113851
	increased IgM level	J:113851
	increased susceptibility to parasitic infection	J:113851
Pdcd1lg2^tm2Shr/Pdcd1lg2^tm2Shr C.B6-Pdcd1lg2^tm2Shr	abnormal dendritic cell physiology	J:123785
	increased interferon-gamma secretion	J:123785
	increased interleukin-2 secretion	J:123785
Pdcd1lg2^tm3Shr/Pdcd1lg2^tm3Shr involves: C57BL/6 * NOD/MrkTac	abnormal CD8-positive, alpha-beta T cell physiology	J:123785
	hyperglycemia	J:123785
	increased CD4-positive, alpha-beta T cell number	J:123785
	increased CD8-positive, alpha-beta T cell number	J:123785
	increased susceptibility to autoimmune diabetes	J:123785
	insulitis	J:123785
	lymph node hyperplasia	J:123785

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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