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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ern1
endoplasmic reticulum to nucleus signalling 1
MGI:1930134
26 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ern1tm1Dron/Ern1+
129S.129S6-Ern1tm1Dron 		abnormal glucose homeostasis J:132805
abnormal response/metabolism to endogenous compounds J:132805
Ern1tm1Dron/Ern1tm1Dron
involves: 129S6/SvEvTac 		embryonic lethality during organogenesis, complete penetrance J:132966
Ern1tm1Rjk/Ern1tm1Rjk
involves: 129S1/Sv * 129X1/SvJ 		abnormal cell physiology J:124971
Ern1tm1Rjk/Ern1tm1Rjk
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal definitive hematopoiesis J:106975
abnormal pro-B cell morphology J:106975
decreased embryo size J:106975
embryonic growth retardation J:106975
embryonic lethality during organogenesis, complete penetrance J:106975
liver hypoplasia J:106975
pallor J:106975
Ern1tm1Rjk/Ern1tm2.1Rjk
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA 		abnormal apolipoprotein level J:171230
abnormal hepatocyte morphology J:171230
abnormal lipid level J:171230
decreased circulating cholesterol level J:171230
hepatic steatosis J:171230
increased hepatocyte apoptosis J:171230
increased liver triglyceride level J:171230
Ern1tm1Tiw/Ern1tm1Tiw
involves: 129S4/SvJae * C57BL/6 		abnormal extraembryonic tissue physiology J:153222
abnormal placenta labyrinth morphology J:153222
abnormal placental labyrinth vasculature morphology J:153222
abnormal placental transport J:153222
abnormal trophoblast layer morphology J:153222
decreased embryo size J:153222
embryonic lethality during organogenesis, complete penetrance J:153222
small placenta J:153222
Ern1tm2.1Rjk/Ern1tm2.1Rjk
Not Specified 		no abnormal phenotype detected J:171230
Ern1tm2.1Tiw/Ern1tm2.2Tiw
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJae * C57BL/6 		normal embryo phenotype J:153222
normal liver/biliary system phenotype J:153222
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory