Stx1b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Stx1b
syntaxin 1B
MGI:1930705

17 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Stx1b^tm1.1Sud/Stx1b^tm1.1Sud involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal adrenal chromaffin cell morphology	J:138035
	abnormal CNS synaptic transmission	J:138035
	abnormal excitatory postsynaptic currents	J:138035
	abnormal miniature excitatory postsynaptic currents	J:138035
	abnormal neuron physiology	J:138035
	abnormal synaptic vesicle recycling	J:138035
	ataxia	J:138035
	premature death	J:138035
	seizures	J:138035
Stx1b^tm1Tmis/Stx1b^tm1Tmis B6.Cg-Stx1b^tm1Tmis	abnormal AMPA-mediated synaptic currents	J:214474
	abnormal CNS synaptic transmission	J:214474
	abnormal GABA-mediated receptor currents	J:214474
	abnormal miniature excitatory postsynaptic currents	J:214474
	abnormal paired-pulse inhibition	J:214474
	abnormal synapse morphology	J:214474
	abnormal synaptic vesicle number	J:214474
	abnormal synaptic vesicle recycling	J:214474
	decreased body size	J:214474
	decreased miniature inhibitory postsynaptic current frequency	J:214474
	postnatal lethality, complete penetrance	J:214474

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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