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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Myh10
myosin, heavy polypeptide 10, non-muscle
MGI:1930780
124 phenotypes from 11 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Myh10b2b2437Clo/Myh10b2b2437Clo
C57BL/6J-Myh10b2b2437Clo 		abnormal cranium morphology J:175213
abnormal myocardium compact layer morphology J:175213
atrioventricular septal defect J:175213
cleft upper lip J:175213
double outlet right ventricle J:175213
double outlet right ventricle with atrioventricular septal defect J:175213
exencephaly J:175213
micrognathia J:175213
overriding aortic valve J:175213
ventricular septal defect J:175213
Myh10ehc/Myh10ehc
involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J 		abnormal heart apex morphology J:248868
abnormal heart atrium morphology J:248868
abnormal heart ventricle morphology J:248868
abnormal myocardium compact layer morphology J:248868
abnormal ventricle myocardium morphology J:248868
absent coronary vessels J:248868
domed cranium J:248868
double outlet right ventricle J:248868
edema J:248868
heart hemorrhage J:248868
hemopericardium J:248868
hydrocephaly J:248868
lethality throughout fetal growth and development, incomplete penetrance J:248868
myocardial trabeculae hypoplasia J:248868
pericardial effusion J:248868
thin interventricular septum J:248868
ventricular septal defect J:248868
Myh10ehc/Myh10tm2Rsad
involves: 129S4/SvJae * 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J 		abnormal heart morphology J:248868
abnormal myocardium compact layer morphology J:248868
absent coronary vessels J:248868
embryonic lethality, complete penetrance J:248868
Myh10em1(IMPC)J/Myh10+
C57BL/6NJ-Myh10em1(IMPC)J/J 		increased fasting circulating glucose level J:211773
Myh10em1(IMPC)J/Myh10em1(IMPC)J
C57BL/6NJ-Myh10em1(IMPC)J/J 		abnormal pericardium morphology J:211773
abnormal placenta size J:211773
abnormal skin coloration J:211773
edema J:211773
embryonic growth retardation J:211773
hemorrhage J:211773
prenatal lethality prior to heart atrial septation J:211773
preweaning lethality, complete penetrance J:211773
Myh10tm1Rsad/Myh10tm1Rsad
involves: 129S4/SvJae 		cardiac hypertrophy J:92230
Myh10tm1Rsad/Myh10tm2Rsad
involves: 129S4/SvJae 		cardiac hypertrophy J:92230
Myh10tm2Rsad/Myh10+
involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 		normal growth/size/body region phenotype J:245570
Myh10tm2Rsad/Myh10tm2Rsad
involves: 129S4/SvJae 		abnormal fetal cardiomyocyte morphology J:92230
abnormal heart morphology J:248868
abnormal myocardium compact layer morphology J:248868
abnormal spinal cord morphology J:124610
absent coronary vessels J:248868
normal cardiovascular system phenotype J:248868
decreased fetal cardiomyocyte number J:92230
decreased fetal cardiomyocyte proliferation J:92230
hydrocephaly J:124610
increased cardiomyocyte apoptosis J:248868
increased fetal cardiomyocyte size J:92230
thin ventricular wall J:92230
Myh10tm2Rsad/Myh10tm2Rsad
involves: 129S4/SvJae * C57BL/6 		abnormal atrioventricular valve development J:245570
abnormal cardiac outflow tract development J:245570
abnormal fetal cardiomyocyte morphology J:168304
abnormal fourth ventricle morphology J:112536
decreased fetal cardiomyocyte number J:168304
double outlet right ventricle J:245570
normal growth/size/body region phenotype J:245570
hydrocephaly J:112536
Myh10tm2Rsad/Myh10tm2Rsad
involves: 129S4/SvJae * C57BL/6J 		abnormal aortic valve morphology J:44181
abnormal birth body size J:44181
abnormal fetal cardiomyocyte morphology J:44181
abnormal liver morphology J:44181
abnormal retina morphology J:44181
abnormal suckling behavior J:44181
absent retina bipolar cells J:44181
congestive heart failure J:44181
dilated heart right atrium J:44181
domed cranium J:44181
fetal cardiomyocyte disarray J:44181
globular heart J:44181
heart right ventricle outflow tract stenosis J:44181
hydrocephaly J:44181
increased fetal cardiomyocyte size J:44181
liver vascular congestion J:44181
neonatal lethality, complete penetrance J:44181
overriding aortic valve J:44181
perimembraneous ventricular septal defect J:44181
prenatal lethality, incomplete penetrance J:44181
Myh10tm2Rsad/Myh10tm3.1Rsad
involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 		failure of ventral body wall closure J:245570
Myh10tm2Rsad/Myh10tm4Rsad
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		abnormal fourth ventricle morphology J:112536
hydrocephaly J:112536
Myh10tm2Rsad/Myh10tm5Rsad
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		abnormal fourth ventricle morphology J:112536
hydrocephaly J:112536
Myh10tm3.1Rsad/Myh10+
involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 		failure of ventral body wall closure J:245570
Myh10tm3.1Rsad/Myh10+
involves: 129S6/SvEvTac * BALB/c * C57BL/6 		abnormal diaphragm development J:245570
normal cardiovascular system phenotype J:245570
diaphragmatic hernia J:245570
herniated liver J:245570
omphalocele J:245570
thin diaphragm muscle J:245570
Myh10tm3.1Rsad/Myh10tm3.1Rsad
involves: 129S6/SvEvTac * BALB/c * C57BL/6 		abnormal atrioventricular valve development J:245570
abnormal cardiac outflow tract development J:245570
abnormal conotruncal ridge morphology J:245570
abnormal diaphragm development J:245570
abnormal sternum morphology J:245570
cleft palate J:245570
congestive heart failure J:245570
decreased apoptosis J:245570
decreased cardiac muscle contractility J:245570
decreased heart rate J:245570
decreased palatal shelf size J:245570
diaphragmatic hernia J:245570
dilated liver sinusoidal space J:245570
double outlet right ventricle J:245570
ectopia cordis J:245570
failure of atrioventricular cushion closure J:245570
failure of palatal shelf elevation J:245570
failure of ventral body wall closure J:245570
generalized edema J:245570
herniated liver J:245570
increased heart left ventricle size J:245570
lethality throughout fetal growth and development, complete penetrance J:92081, J:245570
liver hemorrhage J:245570
liver vascular congestion J:245570
omphalocele J:245570
split sternum J:245570
umbilical hernia J:245570
Myh10tm3Rsad/Myh10tm3Rsad
involves: 129S6/SvEvTac * C57BL/6 		abnormal cerebellar foliation J:92081
abnormal cerebellar granule layer morphology J:92081
abnormal cerebellar molecular layer J:92081
abnormal cerebellum external granule cell layer morphology J:92081
abnormal cerebellum morphology J:92081
abnormal cerebral cortex morphology J:92081
abnormal facial nerve morphology J:92081
abnormal fourth ventricle morphology J:112536
abnormal heart ventricle morphology J:92230
abnormal Purkinje cell morphology J:92081
ataxia J:92081
decreased neuronal migration J:92081
decreased Purkinje cell size J:92081
normal growth/size/body region phenotype J:245570
hydrocephaly J:92081, J:112536
impaired balance J:92081
postnatal lethality, complete penetrance J:92081
small cerebellum J:92081
Myh10tm4Rsad/Myh10tm4Rsad
involves: 129S6/SvEvTac * C57BL/6 		abnormal cerebral aqueduct morphology J:168304
abnormal fourth ventricle morphology J:112536
abnormal myocardial fiber physiology J:168304
abnormal neuronal migration J:112536
dilated brain ventricle J:112536
dilated lateral ventricle J:112536
dilated third ventricle J:112536
hydrocephaly J:112536
postnatal lethality, incomplete penetrance J:112536
Myh10tm5Rsad/Myh10tm5Rsad
involves: 129S6/SvEvTac * C57BL/6 		abnormal cerebellar Purkinje cell layer J:112536
abnormal Purkinje cell dendrite morphology J:112536
ectopic Purkinje cell J:112536
impaired coordination J:112536
normal nervous system phenotype J:112536
Myh10tm5Rsad/Myh10tm5Rsad
Tg(CMV-cre)1Cgn/0
involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 		abnormal cerebellar Purkinje cell layer J:112536
abnormal Purkinje cell dendrite morphology J:112536
ectopic Purkinje cell J:112536
impaired coordination J:112536
Myh10tm7Rsad/Myh10tm7Rsad
Tg(Myh6-cre)2182Mds/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		abnormal atrial thrombosis J:170148
abnormal impulse conducting system conduction J:170148
abnormal intercalated disk morphology J:170148
cardiac interstitial fibrosis J:170148
cardiomyopathy J:170148
decreased cardiac muscle contractility J:170148
heart inflammation J:170148
increased cardiomyocyte apoptosis J:170148
increased myocardial fiber size J:170148
ventricular septal defect J:170148
Myh10tm7Rsad/Myh10tm7Rsad
Tg(Nes-cre)1Wme/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA 		abnormal cerebellum development J:170148
abnormal locomotor behavior J:170148
abnormal spinal cord central canal morphology J:170148
normal cardiovascular system phenotype J:170148
enlarged lateral ventricles J:170148
hydrocephaly J:170148
postnatal lethality, complete penetrance J:170148
thin cerebral cortex J:170148
Myh10tm8Rsad/Myh10tm8Rsad
involves: 129 		no abnormal phenotype detected J:124610
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory