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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tusc2
tumor suppressor 2, mitochondrial calcium regulator
MGI:1931086
47 phenotypes from 1 allele in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tusc2tm1Avi/Tusc2+
involves: 129S1/Sv * C57BL/6J 		abnormal glomerular capillary thrombosis J:119985
abnormal renal glomerulus morphology J:119985
abnormal tumor incidence J:119985
adipose tissue necrosis J:119985
arteritis J:119985
decreased erythrocyte cell number J:119985
glomerulonephritis J:119985
increased anti-nuclear antigen antibody level J:119985
increased hemangioma incidence J:119985
increased hemangiosarcoma incidence J:119985
increased leukemia incidence J:119985
increased lymphoma incidence J:119985
increased susceptibility to autoimmune disorder J:119985
premature death J:119985
renal cast J:119985
vascular inflammation J:119985
Tusc2tm1Avi/Tusc2tm1Avi
involves: 129S1/Sv 		abnormal calcium ion homeostasis J:309768
abnormal cauda epididymis morphology J:309768
abnormal glomerular capillary thrombosis J:309768
abnormal hair growth J:309768
abnormal nursing J:309768
abnormal oxidative phosphorylation J:309768
abnormal pregnancy J:309768
abnormal response to novelty J:309768
abnormal susceptibility to weight gain J:309768
arteritis J:309768
asthenozoospermia J:309768
chronic inflammation J:309768
decreased body weight J:309768
decreased T cell proliferation J:309768
decreased thymocyte number J:309768
enlarged seminal vesicle J:309768
increased macrophage cell number J:309768
increased monocyte cell number J:309768
increased myeloid cell number J:309768
increased physiological sensitivity to xenobiotic J:309768
increased susceptibility to autoimmune disorder J:309768
lordokyphosis J:309768
oligozoospermia J:309768
premature aging J:309768
premature death J:309768
renal tubular necrosis J:309768
small cauda epididymis J:309768
small testis J:309768
testis degeneration J:309768
weakness J:309768
Tusc2tm1Avi/Tusc2tm1Avi
involves: 129S1/Sv * C57BL/6J 		abnormal glomerular capillary thrombosis J:119985
abnormal NK cell differentiation J:119985
abnormal renal glomerulus morphology J:119985
abnormal tumor incidence J:119985
adipose tissue necrosis J:119985
arteritis J:119985
decreased body weight J:119985
decreased erythrocyte cell number J:119985
decreased interleukin-15 secretion J:119985
decreased NK cell number J:119985
glomerulonephritis J:119985
increased anti-nuclear antigen antibody level J:119985
increased hemangioma incidence J:119985
increased hemangiosarcoma incidence J:119985
increased leukocyte cell number J:119985
increased lymphoma incidence J:119985
increased squamous cell carcinoma incidence J:119985
increased susceptibility to autoimmune disorder J:119985
premature death J:119985
renal cast J:119985
vascular inflammation J:119985
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory