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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Wwox
WW domain-containing oxidoreductase
MGI:1931237
103 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Wwoxem1Mald/Wwoxem1Mald
FVB/N-Wwoxem1Mald 		abnormal cerebellum vermis lobule morphology J:339564
abnormal fear/anxiety-related behavior J:339564
abnormal motor capabilities/coordination/movement J:339564
abnormal response to social novelty J:339564
absent cerebellum fissure J:339564
astrocytosis J:339564
cerebellum atrophy J:339564
cerebellum hypoplasia J:339564
cholestasis J:339564
convulsive seizures J:339564
decreased body weight J:339564
decreased locomotor activity J:339564
decreased oligodendrocyte number J:339564
decreased social investigation J:339564
enlarged gallbladder J:339564
normal growth/size/body region phenotype J:339564
normal homeostasis/metabolism phenotype J:339564
impaired coordination J:339564
increased thigmotaxis J:339564
limb grasping J:339564
liver degeneration J:339564
microgliosis J:339564
premature death J:339564
Purkinje cell degeneration J:339564
thin cerebellar granule layer J:339564
thin cerebellar molecular layer J:339564
tonic-clonic seizures J:339564
WwoxGt(XG218)Byg/WwoxGt(XG218)Byg
involves: 129P2/OlaHsd 		decreased survivor rate J:132078
increased B cell derived lymphoma incidence J:132078
increased Leydig cell number J:132078
increased malignant tumor incidence J:132078
premature death J:132078
reduced male fertility J:132078
seminiferous tubule degeneration J:132078
testicular atrophy J:132078
Wwoxtm1.1Mald/Wwoxtm1.1Mald
involves: C57BL/6 * FVB/N 		abnormal thymus cortex morphology J:155406
anemia J:155406
cachexia J:155406
decreased body weight J:155406
decreased bone mineral density J:155406
decreased bone trabecula number J:155406
decreased circulating bicarbonate level J:155406
decreased circulating calcium level J:155406
decreased circulating glucose level J:155406
decreased leukocyte cell number J:155406
decreased liver weight J:155406
decreased osteoblast cell number J:155406
decreased spleen weight J:155406
decreased thymus weight J:155406
decreased trabecular bone thickness J:155406
decreased trabecular bone volume J:155406
increased blood urea nitrogen level J:155406
increased brain weight J:155406
increased circulating chloride level J:155406
normal neoplasm J:155406
postnatal growth retardation J:155406
postnatal lethality, complete penetrance J:155406
small spleen J:155406
spleen atrophy J:155406
Wwoxtm1Mald/Wwoxtm1Mald
involves: 129S6/SvEvTac * C57BL/6 		normal growth/size/body region phenotype J:155406
normal mortality/aging J:155406
normal reproductive system phenotype J:155406
Wwoxtm1Ria/Wwox+
involves: 129X1/SvJ * C57BL/6 		enlarged spleen J:120064
increased incidence of tumors by chemical induction J:120064
increased lung tumor incidence J:120064
increased tumor incidence J:120064
Wwoxtm1Ria/Wwoxtm1Ria
involves: 129X1/SvJ * C57BL/6 		increased osteosarcoma incidence J:120064
premature death J:120064
Wwoxtm1Ria/Wwoxtm1Ria
involves: 129X1/SvJ * C57BL/6J 		abnormal circulating enzyme level J:138140
abnormal homeostasis J:146986
abnormal osteoblast differentiation J:138140
abnormal osteoclast physiology J:138140
abnormal pituitary gland physiology J:146986
abnormal primary ovarian follicle morphology J:146986
abnormal skeleton development J:138140
abnormal skeleton morphology J:138140
abnormal trabecular bone morphology J:138140
cachexia J:138140
decreased body size J:138140
decreased bone mineral density J:138140
decreased circulating alkaline phosphatase level J:138140
decreased circulating aspartate transaminase level J:138140
decreased circulating calcium level J:138140
decreased circulating chloride level J:138140
decreased circulating cholesterol level J:138140
decreased circulating serum albumin level J:138140
decreased circulating sodium level J:138140
decreased circulating testosterone level J:146986
decreased circulating total protein level J:138140
decreased circulating triglyceride level J:138140
decreased compact bone thickness J:138140
decreased Leydig cell number J:146986
decreased theca cell number J:146986
hypoglycemia J:138140
increased adrenal gland weight J:138140
increased blood uric acid level J:138140
increased bone resorption J:138140
increased brain weight J:138140
increased circulating bilirubin level J:138140
increased circulating phosphate level J:138140
increased circulating potassium level J:138140
increased pituitary gland weight J:138140
postnatal growth retardation J:138140
postnatal lethality, complete penetrance J:138140
small ovary J:146986
small seminiferous tubules J:146986
small testis J:146986
testis hypoplasia J:146986
thin uterine horn J:146986
Wwoxtm2.1Ria/Wwoxtm2.1Ria
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		abnormal compact bone morphology J:198845
abnormal trabecular bone morphology J:198845
decreased body weight J:198845
decreased bone mineral density J:198845
decreased bone trabecula number J:198845
decreased compact bone area J:198845
decreased compact bone thickness J:198845
decreased trabecular bone connectivity density J:198845
decreased trabecular bone volume J:198845
hypoglycemia J:198845
increased skeletal tumor incidence J:198845
postnatal growth retardation J:198845
postnatal lethality, complete penetrance J:198845
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory