Dhx58 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dhx58
DExH-box helicase 58
MGI:1931560

24 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dhx58^em1(IMPC)J/Dhx58^em1(IMPC)J C57BL/6NJ-Dhx58^em1(IMPC)J/Mmjax	decreased prepulse inhibition	J:211773
Dhx58^tm1Aki/Dhx58^tm1Aki involves: 129/Sv * C57BL/6	decreased circulating interferon-beta level	J:156867
	decreased interferon-beta secretion	J:156867
	decreased interleukin-6 secretion	J:156867
	enlarged uterus	J:156867
	increased susceptibility to Picornaviridae infection	J:156867
	increased susceptibility to Picornaviridae infection induced morbidity/mortality	J:156867
	prenatal lethality, incomplete penetrance	J:156867
	vagina atresia	J:156867
Dhx58^tm1Gnb/Dhx58^tm1Gnb involves: 129P2/OlaHsd * C57BL/6J	abnormal interferon secretion	J:146113
	abnormal susceptibility to Riboviria infection	J:146113
	decreased interferon-alpha secretion	J:146113
	decreased interferon-beta secretion	J:146113
	decreased susceptibility to induced morbidity/mortality	J:146113
	decreased susceptibility to Riboviria infection	J:146113
	increased circulating interferon-gamma level	J:146113
	increased circulating interleukin-12 level	J:146113
	increased interferon-alpha secretion	J:146113
	increased interferon-beta secretion	J:146113
	increased susceptibility to induced morbidity/mortality	J:146113
	increased susceptibility to Picornaviridae infection	J:146113
Dhx58^tm1Itl/Dhx58^tm1Itl C57BL/6-Dhx58^tm1Itl	decreased interferon-beta secretion	J:187386
	decreased interferon-gamma secretion	J:187386
	decreased tumor necrosis factor secretion	J:187386
	increased susceptibility to Flaviviridae infection	J:187386
	increased susceptibility to Flaviviridae infection induced morbidity/mortality	J:187386
	increased T cell apoptosis	J:187386
Dhx58^tm2.1Aki/Dhx58^tm2.1Aki involves: 129/Sv * C57BL/6	decreased interferon-beta secretion	J:156867
	decreased interleukin-6 secretion	J:156867
	increased susceptibility to Picornaviridae infection	J:156867
	increased susceptibility to Picornaviridae infection induced morbidity/mortality	J:156867

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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