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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Egln1
egl-9 family hypoxia-inducible factor 1
MGI:1932286
85 phenotypes from 11 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Egln1Gt(RRG405)Byg/Egln1Gt(RRG405)Byg
involves: 129P2/OlaHsd 		abnormal heart morphology J:162597
abnormal response of heart to induced stress J:162597
normal cardiovascular system phenotype J:162597
decreased body weight J:162597
normal hematopoietic system phenotype J:162597
Egln1tm1.1Brei/Egln1tm1.1Brei
Myl2tm1(cre)Krc/Myl2+
B6.Cg-Myl2tm1(cre)Krc Egln1tm1.1Brei 		abnormal coronary vessel morphology J:170943
abnormal response to cardiac infarction J:170943
normal cardiovascular system phenotype J:170943
decreased cardiomyocyte apoptosis J:170943
decreased myocardial infarct size J:170943
Egln1tm1.1Brei/Egln1tm1.1Brei
Tg(CD68-icre)1Bwlx/0
involves: C57BL/6 		abnormal blood viscosity J:194598
abnormal lymphocyte cell number J:194598
abnormal megakaryocyte progenitor cell morphology J:194598
abnormal nucleated erythrocyte cell number J:194598
abnormal spleen morphology J:194598
enlarged spleen J:194598
normal hematopoietic system phenotype J:194598
hypervolemia J:194598
increased erythroblast number J:194598
increased hematocrit J:194598
increased spleen weight J:194598
normal mortality/aging J:194598
polycythemia J:194598
postnatal growth retardation J:194598
reddish skin J:194598
thrombocytopenia J:194598
Egln1tm1.1Fsl/Egln1+
C57BL/6-Egln1tm1.1Fsl 		increased hematocrit J:202737
increased hemoglobin content J:202737
increased pulmonary ventilation J:202737
increased spleen weight J:202737
increased tidal volume J:202737
polycythemia J:202737
Egln1tm1.1Fsl/Egln1tm1.1Fsl
C57BL/6-Egln1tm1.1Fsl 		prenatal lethality, complete penetrance J:202737
Egln1tm1.1Kael/Egln1tm1.1Kael
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		lethality during fetal growth through weaning, complete penetrance J:132718
Egln1tm1.2Brei/Egln1tm1.2Brei
B6.Cg-Egln1tm1.2Brei 		preweaning lethality, complete penetrance J:170943
Egln1tm1Fong/Egln1+
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		normal muscle phenotype J:132630
Egln1tm1Fong/Egln1tm1Fong
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL 		abnormal heart morphology J:114669
abnormal heart ventricle morphology J:114669
abnormal interventricular septum morphology J:114669
abnormal lymph organ development J:114669
abnormal placenta labyrinth morphology J:114669
abnormal placenta morphology J:114669
abnormal spongiotrophoblast layer morphology J:114669
abnormal trabecula carnea morphology J:114669
abnormal trophoblast giant cell morphology J:114669
congestive heart failure J:114669
decreased trophoblast giant cell number J:114669
delayed heart development J:114669
embryonic lethality during organogenesis, complete penetrance J:114669
increased heart atrium size J:114669
pale yolk sac J:114669
thin ventricle myocardium compact layer J:114669
Egln1tm1Kael/Egln1tm1Kael
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal myocardium layer morphology J:132718
blood vessel congestion J:132718
cardiac ischemia J:132718
decreased body size J:132718
dilated cardiomyopathy J:132718
hemorrhage J:132718
increased circulating erythropoietin level J:132718
increased myocardial fiber size J:132718
polycythemia J:132718
premature death J:132718
reddish skin J:132718
Egln1tm1Kael/Egln1tm1Kael
Tg(Myh6-cre)2182Mds/0
involves: 129S6/SvEvTac * FVB/N 		abnormal heart left ventricle morphology J:179490
cardiac interstitial fibrosis J:179490
decreased heart ventricle muscle contractility J:179490
decreased mitochondrial number J:179490
enlarged heart J:179490
increased angiogenesis J:179490
increased heart weight J:179490
increased myocardial fiber size J:179490
increased response of heart to induced stress J:179490
liver vascular congestion J:179490
myocardial fiber degeneration J:179490
pulmonary vascular congestion J:179490
Egln1tm1Pec/Egln1tm1Pec
Not Specified 		prenatal lethality, complete penetrance J:148719
Egln1tm2.1Fsl/Egln1+
Pax3tm1(cre)Joe/Pax3+
involves: 129 * C57BL/6 		increased hematocrit J:202737
polycythemia J:202737
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Egln1tm2.1Fsl Commd10Tg(Vav1-icre)A2Kio 		increased erythroid progenitor cell number J:202737
increased hematocrit J:202737
increased hemoglobin content J:202737
polycythemia J:202737
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl 		extramedullary hematopoiesis J:202737
increased erythropoietin level J:202737
increased hematocrit J:202737
increased spleen weight J:202737
polycythemia J:202737
premature death J:202737
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Pax3tm1(cre)Joe/Pax3+
involves: 129 * C57BL/6 		abnormal liver vasculature morphology J:202737
increased heart weight J:202737
increased hematocrit J:202737
increased liver weight J:202737
increased spleen weight J:202737
polycythemia J:202737
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Tg(Cdh5-cre)7Mlia/0
B6.Cg-Egln1tm2.1Fsl Tg(Cdh5-cre)7Mlia 		increased heart weight J:202737
premature death J:202737
Egln1tm2.2Fsl/Egln1+
B6.Cg-Egln1tm2.2Fsl 		increased hematocrit J:202737
increased hemoglobin content J:202737
increased pulmonary ventilation J:202737
increased spleen weight J:202737
polycythemia J:202737
Egln1tm2.2Fsl/Egln1tm2.2Fsl
B6.Cg-Egln1tm2.2Fsl 		prenatal lethality, complete penetrance J:202737
Egln1tm2Fong/Egln1tm2Fong
Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * C57BL/6 		abnormal blood vessel morphology J:133568
abnormal capillary branching pattern J:133568
abnormal capillary morphology J:133568
abnormal definitive hematopoiesis J:132720
abnormal kidney vasculature morphology J:133568
abnormal liver morphology J:132720
abnormal lung vasculature morphology J:133568
abnormal renal glomerulus morphology J:133568
abnormal splenic cell ratio J:132720
decreased survivor rate J:132720
dilated liver sinusoidal space J:133568
dilated vasculature J:133568
enlarged liver J:132720
enlarged spleen J:132720
extramedullary hematopoiesis J:132720
increased angiogenesis J:133568
increased circulating erythropoietin level J:132720
increased hematocrit J:132720
increased hemoglobin content J:132720
increased leukocyte cell number J:132720
polycythemia J:132720
premature death J:132720
reddish skin J:132720
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory