Egln1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Egln1
egl-9 family hypoxia-inducible factor 1
MGI:1932286

23 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Egln1^{Gt(RRG405)Byg}/Egln1^{Gt(RRG405)Byg} P4htm^tm1Jomy/P4htm^tm1Jomy Not Specified	decreased circulating erythropoietin level	J:213191
	increased hematocrit	J:213191
	increased mean corpuscular hemoglobin concentration	J:213191
Egln1^tm1.1Brei/Egln1^tm1.1Brei Egln3^tm2Fong/Egln3^tm2Fong Tg(CD68-icre)1Bwlx/0 involves: 129S6/SvEvTac * C57BL/6	neonatal lethality	J:194598
	polycythemia	J:194598
Egln1^tm1.1Brei/Egln1^tm1.1Brei Epas1^tm1Mcs/Epas1^tm1Mcs Tg(CD68-icre)1Bwlx/0 involves: 129X1/SvJ * C57BL/6	decreased hematocrit	J:194598
	decreased hemoglobin content	J:194598
	normal hematopoietic system phenotype	J:194598
	normal mortality/aging	J:194598
Egln1^tm1.1Brei/Egln1^tm1.1Brei Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Tg(CD68-icre)1Bwlx/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	domed cranium	J:194598
	normal hematopoietic system phenotype	J:194598
	hydrocephaly	J:194598
	increased hematocrit	J:194598
	postnatal lethality	J:194598
Egln1^tm1.1Fsl/Egln1⁺ Hif1a^tm3.1Rsjo/Hif1a⁺ B6.Cg-Egln1^tm1.1Fsl Hif1a^tm3.1Rsjo	increased hematocrit	J:202737
Egln1^tm1Kael/Egln1^tm1Kael Egln3^tm1Vlcg/Egln3^tm1Vlcg Tg(Myh6-cre)2182Mds/0 involves: 129S6/SvEvTac * FVB/N	abnormal heart left ventricle morphology	J:179490
	cardiomyopathy	J:179490
	decreased heart ventricle muscle contractility	J:179490
	decreased mitochondrial number	J:179490
	increased angiogenesis	J:179490
	increased heart weight	J:179490
	myocardial fiber degeneration	J:179490
	premature death	J:179490
Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Epas1^tm1Mcs/Epas1^tm1Mcs Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ B6.Cg-Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} Egln1^tm2.1Fsl Epas1^tm1Mcs	normal hematopoietic system phenotype	J:202737
	premature death	J:202737
Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ Hif1a^tm3Rsjo/Hif1a^tm3Rsjo B6.Cg-Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} Egln1^tm2.1Fsl Hif1a^tm3Rsjo	extramedullary hematopoiesis	J:202737
	increased erythropoietin level	J:202737
	increased hematocrit	J:202737
	increased spleen weight	J:202737
	premature death	J:202737
Egln1^tm2Fong/Egln1^tm2Fong Egln2^tm2Fong/Egln2^tm2Fong Egln3^tm2Fong/Egln3^tm2Fong Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129S6/SvEvTac * C57BL/6NCr * CD-1	increased hematocrit	J:186085

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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