Cacng8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cacng8
calcium channel, voltage-dependent, gamma subunit 8
MGI:1932376

20 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cacng8^tm1.1Mwa/Cacng8^tm1.1Mwa involves: C57BL/6 * C57BL/6N * CBA	abnormal hippocampus pyramidal cell morphology	J:117149
Cacng8^tm1.1Suto/Cacng8^tm1.1Suto Not Specified	abnormal AMPA-mediated synaptic currents	J:179775
	abnormal excitatory postsynaptic currents	J:179775
	abnormal glutamate-mediated receptor currents	J:179775
	abnormal reproductive system physiology	J:179775
	normal mortality/aging	J:179775
	normal nervous system phenotype	J:179775
Cacng8^tm1Ran/Cacng8⁺ C57BL/6-Cacng8^tm1Ran	abnormal behavior	J:322011
	abnormal emotion/affect behavior	J:322011
	abnormal impulsive behavior control	J:322011
	abnormal nest building behavior	J:322011
	abnormal response to novel object	J:322011
	decreased miniature excitatory postsynaptic current amplitude	J:322011
	impaired active avoidance behavior	J:322011
	increased aggression	J:322011
	increased aggression towards mice	J:322011
	increased exploration in new environment	J:322011
Cacng8^tm1Ran/Cacng8^tm1Ran C57BL/6-Cacng8^tm1Ran	abnormal behavior	J:322011
	abnormal emotion/affect behavior	J:322011
	abnormal impulsive behavior control	J:322011
	abnormal nest building behavior	J:322011
	abnormal response to novel object	J:322011
	abnormal response to social novelty	J:322011
	decreased miniature excitatory postsynaptic current amplitude	J:322011
	impaired active avoidance behavior	J:322011
	increased aggression	J:322011
	increased aggression towards mice	J:322011
	increased exploration in new environment	J:322011
Cacng8^tm1Ran/Cacng8^tm1Ran involves: C57BL/6	abnormal synaptic transmission	J:102515
	decreased miniature excitatory postsynaptic current amplitude	J:197912
	reduced long-term potentiation	J:102515, J:179775

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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