Tlr9 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tlr9
toll-like receptor 9
MGI:1932389

27 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Fas^lpr/Fas^lpr Tlr9^tm1Aki/Tlr9^tm1Aki B6.Cg-Tlr9^tm1Aki Fas^lpr	autoimmune response	J:135036
	decreased IgM level	J:135036
	enlarged lymph nodes	J:135036
	enlarged spleen	J:135036
	glomerulonephritis	J:135036
	increased double-negative T cell number	J:135036
	increased IgG level	J:135036
	increased urine protein level	J:135036
	premature death	J:135036
	renal glomerular immunoglobulin deposits	J:135036
Fas^lpr/Fas^lpr Tlr9^tm1Aki/Tlr9^tm1Aki MRL.Cg-Tlr9^tm1Aki Fas^lpr	abnormal B cell activation	J:113557
	abnormal plasmacytoid dendritic cell physiology	J:113557
	abnormal renal glomerulus morphology	J:113557
	decreased autoantibody level	J:113557
	enlarged lymph nodes	J:113557
	enlarged spleen	J:113557
	glomerulonephritis	J:113557
	increased autoantibody level	J:113557
	increased CD4-positive, alpha-beta T cell number	J:113557
	increased circulating interferon-alpha level	J:113557
	increased double-negative T cell number	J:113557
	increased IgG2a level	J:113557
	increased IgG3 level	J:113557
	increased IgG level	J:113557
	increased susceptibility to systemic lupus erythematosus	J:113557
	kidney inflammation	J:113557
	premature death	J:113557
Pld4^tm1.2Nemz/Pld4^tm1.2Nemz Tlr9^M7Btlr/Tlr9^M7Btlr involves: 129 * C57BL/6J * FVB/N	normal hematopoietic system phenotype	J:281205
	normal homeostasis/metabolism phenotype	J:281205
	normal immune system phenotype	J:281205
Smcr8^em1Btlr/Smcr8^em1Btlr Tlr3^tm1Flv/Tlr3^tm1Flv Tlr7^tm1Aki/Tlr7^tm1Aki Tlr9^tm1Aki/Tlr9^tm1Aki involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J	normal immune system phenotype	J:268243
Tlr9^tm1Aki/Tlr9^tm1Aki Tg(IghelMD4)4Ccg/0 Tg(KLK4mHEL)6Ccg/0 involves: 129P2/OlaHsd * C57BL/6	decreased mature B cell number	J:115059
	increased B-1 B cell number	J:115059
Tlr9^tm1Aki/Tlr9^tm1Aki Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy involves: 129P2/OlaHsd * C57BL/6	premature death	J:174308
	thrombocytopenia	J:174308

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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