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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tm6sf2
transmembrane 6 superfamily member 2
MGI:1933210
20 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tm6sf2em1Yech/Tm6sf2em1Yech
C57BL/6-Tm6sf2em1Yech 		abnormal cholesterol homeostasis J:235704
decreased circulating cholesterol level J:235704
decreased circulating HDL cholesterol level J:235704
decreased circulating LDL cholesterol level J:235704
normal homeostasis/metabolism phenotype J:235704
increased circulating triglyceride level J:235704
normal liver/biliary system phenotype J:235704
Tm6sf2tm1a(KOMP)Wtsi/Tm6sf2+
C57BL/6N-Tm6sf2tm1a(KOMP)Wtsi 		abnormal cholesterol homeostasis J:234195
increased liver triglyceride level J:234195
Tm6sf2tm1a(KOMP)Wtsi/Tm6sf2tm1a(KOMP)Wtsi
C57BL/6N-Tm6sf2tm1a(KOMP)Wtsi 		abnormal cholesterol homeostasis J:234195
abnormal circulating apolipoprotein level J:234195
abnormal enterocyte morphology J:234195
abnormal intestinal lipid absorption J:234195
decreased circulating cholesterol level J:234195
decreased circulating HDL cholesterol level J:234195
decreased circulating LDL cholesterol level J:234195
decreased circulating VLDL triglyceride level J:234195
decreased intestinal cholesterol absorption J:234195
hepatic steatosis J:234195
increased circulating alanine transaminase level J:234195
increased circulating triglyceride level J:234195
increased liver triglyceride level J:234195
increased triglyceride level J:234195
Tm6sf2tm1b(KOMP)Wtsi/Tm6sf2tm1b(KOMP)Wtsi
C57BL/6N-Tm6sf2tm1b(KOMP)Wtsi/H 		decreased circulating alkaline phosphatase level J:211773
decreased circulating cholesterol level J:211773
decreased circulating HDL cholesterol level J:211773
increased circulating alanine transaminase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating iron level J:211773
thrombocytopenia J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory