Trim8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Trim8
tripartite motif-containing 8
MGI:1933302

29 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/0 Tg(CAG-cat,-Trim8)4Holi/0 involves: C57BL/6J FVB/N	cardiovascular system phenotype	J:303651
	growth/size/body region phenotype	J:303651
	increased susceptibility to induced morbidity/mortality	J:303651
	mortality/aging	J:303651
	reproductive system phenotype	J:303651
Trim8^{em1(IMPC)Wtsi}/Trim8^{em1(IMPC)Wtsi} C57BL/6N-Trim8^{em1(IMPC)Wtsi}/Wtsi	decreased circulating cholesterol level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	decreased circulating serum albumin level	J:211773
	increased body length	J:211773
	increased mean corpuscular hemoglobin	J:211773
Trim8^em1Holi/Trim8^em1Holi involves: C57BL/6J	normal cardiovascular system phenotype	J:303651
	decreased susceptibility to induced morbidity/mortality	J:303068, J:303651
	normal growth/size/body region phenotype	J:303651
	normal mortality/aging	J:303651
	normal reproductive system phenotype	J:303651
Trim8^tm1Hbsh/Trim8^tm1Hbsh involves: 129S6/SvEvTac	abnormal chemokine secretion	J:251270
	abnormal circulating chemokine level	J:251270
	decreased interleukin-6 secretion	J:251270
	decreased tumor necrosis factor secretion	J:251270
	normal immune system phenotype	J:251270
	increased circulating interleukin-6 level	J:251270
	increased circulating tumor necrosis factor level	J:251270
	increased interferon-beta secretion	J:251270
	increased interleukin-6 secretion	J:251270
	increased macrophage cytokine production	J:251270
	increased susceptibility to bacterial infection	J:251270
	increased susceptibility to bacterial infection induced morbidity/mortality	J:251270
	increased susceptibility to endotoxin shock	J:251270
	increased susceptibility to induced morbidity/mortality	J:251270
	increased tumor necrosis factor secretion	J:251270

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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