Pole3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pole3
polymerase (DNA directed), epsilon 3 (p17 subunit)
MGI:1933378

26 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pole3^em1(IMPC)J/Pole3⁺ C57BL/6NJ-Pole3^em1(IMPC)J/Mmjax	increased grip strength	J:211773
Pole3^em1(IMPC)J/Pole3^em1(IMPC)J C57BL/6NJ-Pole3^em1(IMPC)J/Mmjax	preweaning lethality, complete penetrance	J:211773
Pole3^em1Tbo/Pole3^em1Tbo FVB-Pole3^em1Tbo	decreased B cell number	J:298827
	decreased lymphocyte cell number	J:298827
	decreased splenocyte number	J:298827
	decreased thymocyte number	J:298827
	normal embryo phenotype	J:298827
	normal mortality/aging	J:298827
Pole3^em2Tbo/Pole3^em2Tbo FVB-Pole3^em2Tbo	decreased B cell number	J:298827
	decreased lymphocyte cell number	J:298827
	decreased splenocyte number	J:298827
	decreased thymocyte number	J:298827
	normal embryo phenotype	J:298827
	normal mortality/aging	J:298827
Pole3^em3Tbo/Pole3^em3Tbo FVB-Pole3^em3Tbo	abnormal cell cycle	J:298827
	abnormal thymus apoptosis	J:298827
	decreased B cell number	J:298827
	decreased DN4 thymocyte number	J:298827
	decreased double-positive T cell number	J:298827
	decreased gamma-delta T cell number	J:298827
	decreased immature B cell number	J:298827
	decreased lymphocyte cell number	J:298827
	decreased pre-B cell number	J:298827
	decreased splenocyte number	J:298827
	decreased thymocyte number	J:298827
	normal embryo phenotype	J:298827
	increased DN3 thymocyte number	J:298827
	increased thymocyte apoptosis	J:298827
	normal mortality/aging	J:298827
	small spleen	J:298827
	small thymus	J:298827
Pole3^em4Tbo/Pole3^em4Tbo FVB-Pole3^em4Tbo	abnormal thymus apoptosis	J:298827
	decreased B cell number	J:298827
	decreased DN4 thymocyte number	J:298827
	decreased immature B cell number	J:298827
	decreased lymphocyte cell number	J:298827
	decreased pre-B cell number	J:298827
	decreased splenocyte number	J:298827
	decreased thymocyte number	J:298827
	normal embryo phenotype	J:298827
	increased DN3 thymocyte number	J:298827
	increased thymocyte apoptosis	J:298827
	normal mortality/aging	J:298827
	preweaning lethality, incomplete penetrance	J:298827
Pole3^{tm1(KOMP)Vlcg}/Pole3^{tm1(KOMP)Vlcg} involves: C57BL/6NTac * FVB	abnormal brain development	J:298827
	decreased DN4 thymocyte number	J:298827
	decreased fetal size	J:298827
	delayed bone ossification	J:298827
	increased DN3 thymocyte number	J:298827
	lethality throughout fetal growth and development, complete penetrance	J:298827
	short tail	J:298827
	vertebral fusion	J:298827

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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