Erap1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Erap1
endoplasmic reticulum aminopeptidase 1
MGI:1933403

24 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Erap1^tm1.1Gnie/Erap1^tm1.1Gnie involves: 129S6/SvEvTac * C57BL/6	abnormal antigen presentation	J:143988
	abnormal cytotoxic T cell physiology	J:143988
	abnormal response to infection	J:143988
	decreased interferon-gamma secretion	J:143988
	decreased level of surface class I molecules	J:143988
	decreased T cell proliferation	J:143988
Erap1^tm1Dgen/Erap1^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	enlarged kidney	J:101679
	enlarged spleen	J:101679
	extramedullary hematopoiesis	J:101679
	thymus hyperplasia	J:101679
Erap1^tm1Iay/Erap1^tm1Iay involves: C57BL/6	abnormal cytotoxic T cell physiology	J:111047
Erap1^tm1Iay/Erap1^tm1Iay involves: C57BL/6	decreased level of surface class I molecules	J:111047
Erap1^tm1Luc/Erap1⁺ involves: 129S6/SvEvTac	abnormal antigen presentation	J:122479
Erap1^tm1Luc/Erap1⁺ involves: 129S6/SvEvTac	decreased level of surface class I molecules	J:122479
Erap1^tm1Luc/Erap1^tm1Luc involves: 129S6/SvEvTac	abnormal antigen presentation	J:122479
	abnormal CD8-positive, alpha-beta T cell physiology	J:122479
	abnormal lymphocyte physiology	J:122479
	decreased level of surface class I molecules	J:122479
	normal immune system phenotype	J:122479
	increased level of surface class I molecules	J:122479
Erap1^tm1Nsha/Erap1^tm1Nsha B6.129S6-Erap1^tm1Nsha	abnormal antigen presentation via MHC class I	J:112389, J:116606
	abnormal CD8-positive, alpha-beta T cell physiology	J:112389, J:116606
	abnormal cytokine secretion	J:116606
	decreased level of surface class I molecules	J:112389
Erap1^{tm2b(EUCOMM)Wtsi}/Erap1^{tm2b(EUCOMM)Wtsi} C57BL/6N-Erap1^{tm2b(EUCOMM)Wtsi}/Kmpc	abnormal liver morphology	J:211773
	decreased bone mineral content	J:211773
	decreased circulating serum albumin level	J:211773
	decreased total body fat amount	J:211773
	hyperactivity	J:211773
	increased circulating calcium level	J:211773
	increased lean body mass	J:211773
	thrombocytosis	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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