Nedd4l Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
MGI:1933754

42 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nedd4l^andi/Nedd4l^andi BALB/cByJ-Nedd4l^andi/EiJ	abnormal renal tubule morphology	J:165247
	decreased urine osmolality	J:165173, J:165247
	hydronephrosis	J:165173
	polydipsia	J:165173, J:165247
	polyuria	J:165173, J:165247
Nedd4l^tm1.1Hkb/Nedd4l^tm1.1Hkb Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	abnormal lung morphology	J:169296
	abnormal trachea morphology	J:169296
	abnormal tracheal ciliated epithelium morphology	J:169296
	increased respiratory mucosa goblet cell number	J:169296
	lung inflammation	J:169296
	postnatal lethality, complete penetrance	J:169296
	pulmonary fibrosis	J:169296
Nedd4l^tm1.2Blyg/Nedd4l^tm1.2Blyg involves: 129X1/SvJ * C57BL/6J	abnormal systemic arterial blood pressure	J:148641
	decreased cardiac muscle contractility	J:148641
	decreased heart rate	J:148641
	decreased intestinal epithelial sodium ion transmembrane transport	J:148641
	hypertension	J:148641
	increased circulating aldosterone level	J:148641
	increased circulating potassium level	J:148641
	increased circulating sodium level	J:148641
	increased fluid intake	J:148641
	increased heart left ventricle weight	J:148641
	polyuria	J:148641
	salt-sensitive hypertension	J:148641
Nedd4l^{tm1b(KOMP)Wtsi}/Nedd4l^{tm1b(KOMP)Wtsi} C57BL/6N-Nedd4l^{tm1b(KOMP)Wtsi}/H	abnormal auditory brainstem response	J:211773
	abnormal retina morphology	J:211773
	abnormal startle reflex	J:211773
	decreased exploration in new environment	J:211773
	decreased locomotor activity	J:211773
	decreased prepulse inhibition	J:211773
	decreased startle reflex	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Nedd4l^tm1Shkr/Nedd4l⁺ involves: C57BL/6 * C57BL/6J	increased mean systemic arterial blood pressure	J:205657
Nedd4l^tm1Shkr/Nedd4l^tm1Shkr involves: 129 * C57BL/6 * C57BL/6J	lung inflammation	J:205657
	normal mortality/aging	J:205657
	premature death	J:205657
Nedd4l^tm1Shkr/Nedd4l^tm1Shkr involves: C57BL/6 * C57BL/6J	abnormal pulmonary alveolus morphology	J:205657
	cyanosis	J:205657
	increased neutrophil cell number	J:205657
	lung inflammation	J:205657
	neonatal lethality, incomplete penetrance	J:205657
	postnatal lethality, complete penetrance	J:205657
	primary atelectasis	J:205657
	pulmonary epithelial necrosis	J:205657
	respiratory distress	J:205657
	normal respiratory system phenotype	J:205657

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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