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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Jam3
junction adhesion molecule 3
MGI:1933825
62 phenotypes from 6 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Jam3tm1.1(KOMP)Vlcg/Jam3+
C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J 		abnormal skeletal muscle morphology J:211773
abnormal sleep behavior J:211773
decreased fasting circulating glucose level J:211773
Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J 		male infertility J:211773
preweaning lethality, incomplete penetrance J:211773
Jam3tm1.1Chav/Jam3tm1.1Chav
Tg(Tal1-cre/ERT)1Jrg/?
involves: 129 * C57BL/6 		decreased metastatic potential J:173391
Jam3tm1.1Chav/Jam3tm1.2Chav
Tg(Cdh5-cre)7Mlia/?
involves: 129 * C57BL/6 * FVB/N 		decreased metastatic potential J:173391
Jam3tm1.2Chav/Jam3tm1.2Chav
B6.129-Jam3tm1.2Chav 		decreased metastatic potential J:173391
male infertility J:173391
prenatal lethality, incomplete penetrance J:173391
preweaning lethality, incomplete penetrance J:173391
Jam3tm1.2Chav/Jam3tm1.2Chav
involves: 129 * C57BL/6 		male infertility J:173391
prenatal lethality, incomplete penetrance J:173391
preweaning lethality, incomplete penetrance J:173391
Jam3tm1Lex/Jam3tm1Lex
involves: 129S5/SvEvBrd * C57BL/6 		abnormal behavior J:281813
azoospermia J:145994, J:281813
normal cardiovascular system phenotype J:281813
cyanosis J:145994
decreased locomotor activity J:281813
decreased neutrophil cell number J:145994
enlarged esophagus J:145994, J:281813
increased bone marrow cell number J:145994
increased common myeloid progenitor cell number J:145994
increased erythroid progenitor cell number J:145994
increased granulocyte number J:145994
male infertility J:145994
perinatal lethality, incomplete penetrance J:145994
postnatal growth retardation J:281813
premature death J:281813
Jam3tm1Rha/Jam3tm1.1Chav
Tg(Spo11-cre)D5Mpel/0
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal manchette morphology J:166888
abnormal spermatid morphology J:166888
arrest of spermatogenesis J:166888
decreased male germ cell number J:166888
increased male germ cell apoptosis J:166888
small testis J:166888
Jam3tm1Rha/Jam3tm1Rha
B6.129P2-Jam3tm1Rha 		abnormal cerebral cortex morphology J:191990
abnormal cerebral cortex pyramidal cell morphology J:191990
abnormal cranium morphology J:191990
abnormal gait J:191990
abnormal hippocampus morphology J:191990
abnormal innervation J:191990
abnormal nervous system physiology J:191990
cerebellum atrophy J:191990
dilated lateral ventricle J:191990
disheveled coat J:191990
enlarged cranium J:191990
gliosis J:191990
hydrocephaly J:191990
intracranial hemorrhage J:191990
intraventricular hemorrhage J:191990
lethargy J:191990
obstructive hydrocephaly J:191990
postnatal growth retardation J:191990
postnatal lethality, incomplete penetrance J:191990
subarachnoid hemorrhage J:191990
thin cerebral cortex J:191990
tremors J:191990
Jam3tm1Rha/Jam3tm1Rha
involves: 129P2/OlaHsd * C57BL/6 		abnormal digestive system physiology J:121841
abnormal respiratory system physiology J:121841
abnormal seminiferous tubule morphology J:92665
arrest of spermatogenesis J:92665
enlarged esophagus J:121841
globozoospermia J:92665
increased granulocyte number J:121841
increased susceptibility to bacterial infection J:121841
lung inflammation J:121841
male infertility J:92665, J:121841
postnatal lethality J:92665
postnatal lethality, incomplete penetrance J:121841
small testis J:92665
Jam3tm1Rha/Jam3tm1Rha
Tg(Tek-Jam3)1Maal/0
B6.Cg-Jam3tm1Rha Tg(Tek-Jam3)1Maal 		hydrocephaly J:191990
postnatal lethality, incomplete penetrance J:191990
Jam3tm1Rha/Jam3tm1Rha
Tg(Tek-Jam3)1Maal/?
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA 		enlarged esophagus J:121841
normal immune system phenotype J:121841
male infertility J:121841
normal mortality/aging J:121841
Tg(Tek-Jam3)1Maal/?
B6.Cg-Tg(Tek-Jam3)1Maal 		abnormal cellular extravasation J:99020
abnormal leukocyte adhesion J:99020
abnormal leukocyte physiology J:99020
impaired neutrophil chemotaxis J:99020
lung inflammation J:99020
peritoneal inflammation J:99020
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory