Cilk1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cilk1
ciliogenesis associated kinase 1
MGI:1934157

57 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cilk1^tm1.1Zfu/Cilk1^tm1.1Zfu B6.Cg-Cilk1^tm1.1Zfu/Zfu	abnormal branching involved in lung morphogenesis	J:309653
	abnormal cervical flexure morphology	J:309376
	abnormal chest morphology	J:309376
	abnormal chondrocyte differentiation	J:309376
	abnormal endochondral bone ossification	J:309376
	abnormal hindlimb morphology	J:309376
	abnormal intervertebral disk development	J:309376
	abnormal intervertebral disk morphology	J:309376
	abnormal long bone epiphyseal plate proliferative zone	J:309376
	abnormal long bone morphology	J:309376
	abnormal lung alveolus development	J:309653
	abnormal lung bud morphology	J:309653
	abnormal lung saccule morphology	J:309653
	abnormal lung-associated mesenchyme development	J:309653
	abnormal neck morphology	J:309376
	abnormal primary cilium morphology	J:309653
	abnormal tarsal bone morphology	J:309376
	abnormal thoracic cage morphology	J:309376
	abnormal vertebrae morphology	J:309376
	abnormal vertebral column morphology	J:309376
	abnormal vertebral transverse process morphology	J:309376
	absent nucleus pulposus	J:309376
	broad head	J:309376
	decreased bone mineralization	J:309376
	decreased bone ossification	J:309376
	decreased length of long bones	J:309376
	decreased mesenchymal cell proliferation involved in lung development	J:309653
	enhanced autophagy	J:309653
	increased mouth size	J:309376
	neonatal lethality, complete penetrance	J:309653
	polydactyly	J:309376, J:309653
	pulmonary hypoplasia	J:309653
	respiratory failure	J:309653
	short femur	J:309376
	short limbs	J:309376, J:309653
	short neck	J:309376
	small snout	J:309376
	thick lung-associated mesenchyme	J:309653
Cilk1^{tm1a(KOMP)Mbp}/Cilk1^{tm1a(KOMP)Mbp} C57BL/6N-Cilk1^{tm1a(KOMP)Mbp}	abnormal bone mineralization	J:211652
	abnormal digit development	J:211652
	abnormal kidney development	J:211652
	abnormal long bone morphology	J:211652
	abnormal primary cilium morphology	J:211652
	abnormal skeleton development	J:211652
	abnormal tongue morphology	J:211652
	abnormal ulna morphology	J:211652
	cleft palate	J:211652
	decreased length of long bones	J:211652
	decreased tongue size	J:211652
	delayed bone ossification	J:211652
	dilated brain ventricle	J:211652
	edema	J:211652
	hydrocephaly	J:211652
	lethality throughout fetal growth and development, complete penetrance	J:211652
	normal nervous system phenotype	J:211652
	preaxial polydactyly	J:211652
	short limbs	J:211652
Cilk1^{tm1b(KOMP)Mbp}/Cilk1^{tm1b(KOMP)Mbp} C57BL/6N-Cilk1^{tm1b(KOMP)Mbp}/Ucd	abnormal heart morphology	J:211773
	enlarged heart	J:211773
	increased basophil cell number	J:211773
	increased neutrophil cell number	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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