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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Setdb1
SET domain, bifurcated 1
MGI:1934229
33 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Setdb1tm1.1Yshk/Setdb1tm1.1Yshk
Emx2tm2(cre)Sia/Emx2+
involves: C57BL/6NCrlj * CBA/JNCrlj
abnormal astrocyte morphology J:188109
abnormal cerebral cortex morphology J:188109
abnormal cortical plate morphology J:188109
abnormal nervous system development J:188109
abnormal neuron differentiation J:188109
abnormal neuronal precursor proliferation J:188109
abnormal telencephalon development J:188109
decreased neuron number J:188109
decreased neuronal precursor cell number J:188109
increased neuron apoptosis J:188109
increased neuron number J:188109
loss of cortex neurons J:188109
postnatal lethality, complete penetrance J:188109
Setdb1tm1.1Yshk/Setdb1tm1.1Yshk
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * CBA/J
abnormal palatal mesenchymal cell proliferation J:321816
abnormal secondary palate development J:321816
abnormal tooth development J:321816
cleft secondary palate J:321816
delayed palatal shelf elevation J:321816
neonatal lethality, complete penetrance J:321816
tongue hypoplasia J:321816
Setdb1tm1.1Yshk/Setdb1tm1.1Yshk
Tg(Nes-cre)1Kag/0
Not Specified
abnormal astrocyte morphology J:188109
postnatal lethality, complete penetrance J:188109
Setdb1tm1a(EUCOMM)Wtsi/Setdb1tm1a(EUCOMM)Wtsi
B6Brd;B6Dnk;B6N-Tyrc-Brd Setdb1tm1a(EUCOMM)Wtsi/Wtsi
preweaning lethality, complete penetrance J:211773
Setdb1tm1Enl/Setdb1tm1Enl
involves: 129S4/SvJae
decreased inner cell mass proliferation J:89058
embryonic lethality between implantation and somite formation, complete penetrance J:89058
Setdb1tm2.1Enl/Setdb1tm2.1Enl
involves: 129/Sv * C57BL/6
no abnormal phenotype detected J:161089
Setdb1tm2.1Enl/Setdb1tm2.2Enl
involves: 129/Sv * C57BL/6
abnormal cell morphology J:161089
decreased cell proliferation J:161089
Setdb1tm2.2Enl/Setdb1tm2.2Enl
involves: 129/Sv * C57BL/6
embryonic lethality between implantation and placentation, complete penetrance J:161089
Tg(Camk2a-Setdb1)1Akba/0
involves: C57BL/6 * SJL
abnormal depression-related behavior J:160826
abnormal excitatory postsynaptic potential J:160826
abnormal NMDA-mediated synaptic currents J:160826
normal behavior/neurological phenotype J:160826, J:178512
impaired coordination J:160826
normal mortality/aging J:178512

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory