Ube2n Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ube2n
ubiquitin-conjugating enzyme E2N
MGI:1934835

24 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19^tm1(cre)Cgn/Cd19⁺ Ube2n^tm1Aki/Ube2n^tm1Aki involves: 129P2/OlaHsd * C57BL/6	abnormal B cell physiology	J:112287
	abnormal humoral immune response	J:112287
	abnormal spleen marginal zone morphology	J:112287
	decreased B cell number	J:112287
	decreased B cell proliferation	J:112287
	decreased immunoglobulin level	J:112287
	decreased marginal zone B cell number	J:112287
	increased B cell apoptosis	J:112287
Ube2n^{em1(IMPC)Ccpcz}/Ube2n⁺ C57BL/6N-Ube2n^{em1(IMPC)Ccpcz}/Ccpcz	abnormal joint morphology	J:211773
	abnormal seminal vesicle morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	enlarged spleen	J:211773
	enlarged thymus	J:211773
	hyperactivity	J:211773
Ube2n^{em1(IMPC)Ccpcz}/Ube2n^{em1(IMPC)Ccpcz} C57BL/6N-Ube2n^{em1(IMPC)Ccpcz}/Ccpcz	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Ube2n^{Gt(OST374154)Lex}/Ube2n⁺ involves: 129S5/SvEvBrd * C57BL/6	abnormal leukocyte physiology	J:120846
	abnormal macrophage physiology	J:120846
	decreased B cell proliferation	J:120846
	decreased susceptibility to endotoxin shock	J:120846
	decreased T cell proliferation	J:120846
Ube2n^{Gt(OST374154)Lex}/Ube2n^{Gt(OST374154)Lex} involves: 129S5/SvEvBrd * C57BL/6	embryonic lethality between implantation and somite formation, complete penetrance	J:120846
Ube2n^tm1Aki/Ube2n^tm1Aki involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:112287
Ube2n^tm1Aki/Ube2n^tm1Aki Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal macrophage physiology	J:112287
Ube2n^tm2Aki/Ube2n^tm2Aki involves: 129P2/OlaHsd * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:112287

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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