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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Vangl2
VANGL planar cell polarity 2
MGI:2135272
84 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Ankrd6tm1Pche/Ankrd6tm1Pche
Vangl2Lp/Vangl2+
involves: 129 * LPT/LeJ 		abnormal cochlear hair cell morphology J:216288
abnormal cochlear outer hair cell morphology J:216288
female infertility J:216288
vagina atresia J:216288
Bbs1Gt1Nk/Bbs1+
Vangl2Lp/Vangl2+
involves: 129S7/SvEvBrd * LPT/LeJ 		abnormal orientation of outer hair cell stereociliary bundles J:102697
abnormal outer hair cell stereociliary bundle morphology J:102697
embryonic lethality during organogenesis, incomplete penetrance J:102697
Celsr1Crsh/Celsr1+
Vangl2Lp/Vangl2+
C3H.Cg-Vangl2Lp Celsr1Crsh 		abnormal eyelid morphology J:216413
abnormal left-right axis patterning J:216413
craniorachischisis J:216413
omphalocele J:216413
Celsr1Crsh/Celsr1+
Vangl2Lp/Vangl2+
involves: 101/H * BALB/c * C3H/HeH * CBA * LPT/Le 		craniorachischisis J:216413
curly tail J:216413
Celsr1Crsh/Celsr1+
ScribCrc/Scrib+
Vangl2Lp/Vangl2+
C3H.Cg-Vangl2Lp ScribCrc Celsr1Crsh 		abnormal tail morphology J:216413
craniorachischisis J:216413
exencephaly J:216413
Cfl1c5/Cfl1c5
Vangl2Lp/Vangl2Lp
involves: C57BL/6J * LPT/LeJ 		abnormal direction of heart looping J:194042
abnormal embryo turning J:194042
abnormal embryonic cilium location or orientation J:194042
abnormal heart looping J:194042
abnormal left-right axis patterning J:194042
abnormal notochord morphology J:194042
abnormal primitive node morphology J:194042
abnormal somite development J:194042
abnormal somite size J:194042
decreased embryo size J:194042
embryonic growth arrest J:194042
embryonic lethality during organogenesis, complete penetrance J:194042
failure of heart looping J:194042
heterotaxia J:194042
open neural tube J:194042
Cfl1tm1.2Wit/Cfl1tm1.2Wit
Vangl2Lp/Vangl2Lp
involves: 129 * LPT/LeJ 		abnormal embryo turning J:194042
abnormal somite development J:194042
decreased embryo size J:194042
embryonic growth arrest J:194042
embryonic lethality during organogenesis, complete penetrance J:194042
open neural tube J:194042
CoblC101/CoblC101
Vangl2Lp/Vangl2+
involves: 129S2/SvPas * LPT/LeJ 		exencephaly J:85744
CoblC101/CoblC101
Vangl2Lp/Vangl2Lp
involves: 129S2/SvPas * LPT/LeJ 		exencephaly J:85744
Cthrc1tm1Hssk/Cthrc1+
Vangl2Lp/Vangl2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal neural tube closure J:140886
normal hearing/vestibular/ear phenotype J:140886
Cthrc1tm1Hssk/Cthrc1+
Vangl2Lp/Vangl2+
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		normal nervous system phenotype J:140886
Cthrc1tm1Hssk/Cthrc1tm1Hssk
Vangl2Lp/Vangl2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cochlear hair cell morphology J:140886
abnormal cochlear inner hair cell morphology J:140886
Dact1tm1.1Bnrc/Dact1+
Vangl2Lp/Vangl2+
B6.Cg-Vangl2Lp Dact1tm1.1Bnrc 		curly tail J:152701
Dact1tm1.1Bnrc/Dact1+
Vangl2Lp-m1Jus/Vangl2+
involves: 101/Rl * 129 * C3H/Rl * C57BL/6 		curly tail J:152701
Dact1tm1.1Bnrc/Dact1tm1.1Bnrc
Vangl2Lp-m1Jus/Vangl2+
involves: 101/Rl * 129 * C3H/Rl * C57BL/6 		abnormal anus morphology J:152701
abnormal digestive system morphology J:152701
abnormal external female genitalia morphology J:152701
abnormal external male genitalia morphology J:152701
abnormal kidney morphology J:152701
abnormal urinary bladder morphology J:152701
caudal body truncation J:152701
curly tail J:152701
Dact1tm1.1Bnrc/Dact1tm1.1Bnrc
Vangl2Lp/Vangl2+
B6.Cg-Vangl2Lp Dact1tm1.1Bnrc 		abnormal anus morphology J:152701
abnormal digestive system morphology J:152701
abnormal external female genitalia morphology J:152701
abnormal external male genitalia morphology J:152701
abnormal kidney morphology J:152701
abnormal urinary bladder morphology J:152701
caudal body truncation J:152701
curly tail J:152701
Dact1tm1.1Bnrc/Dact1tm1.1Bnrc
Vangl2Lp/Vangl2Lp
B6.Cg-Vangl2Lp Dact1tm1.1Bnrc 		craniorachischisis J:152701
Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2tm1Awb
Vangl2Lp/Vangl2+
involves: 129S6/SvEvTac * LPT/LeJ 		craniorachischisis J:108512
neonatal lethality, complete penetrance J:108512
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Vangl2Lp/Vangl2Lp
involves: 129S6/SvEvTac * LPT/LeJ 		craniorachischisis J:108512
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2/EGFP)2Awb/?
Vangl2Lp/Vangl2+
involves: 129S6/SvEvTac * LPT/LeJ 		no abnormal phenotype detected J:108512
Dvl2tm1Awb/Dvl2tm1Awb
Vangl2Lp/Vangl2+
involves: 129S6/SvEvTac * LPT/LeJ 		abnormal cochlear inner hair cell morphology J:108512
abnormal embryo development J:108512
abnormal organ of Corti morphology J:100861
abnormal orientation of cochlear hair cell stereociliary bundles J:100861
craniorachischisis J:108512
increased cochlear hair cell number J:100861
neonatal lethality, complete penetrance J:108512
Dvl3tm1Awb/Dvl3+
Vangl2Lp/Vangl2+
involves: 129S6/SvEvTac * A * Black Swiss 		abnormal neural tube morphology J:142392
abnormal orientation of cochlear hair cell stereociliary bundles J:142392
normal cardiovascular system phenotype J:142392
craniorachischisis J:142392
decreased cochlear outer hair cell number J:142392
exencephaly J:142392
incomplete rostral neuropore closure J:142392
increased cochlear hair cell number J:142392
inner ear hypoplasia J:142392
Dvl3tm1Awb/Dvl3tm1Awb
Vangl2Lp/Vangl2+
involves: 129S6/SvEvTac * A * Black Swiss 		abnormal cardiac outflow tract development J:142392
abnormal neural tube morphology J:142392
abnormal orientation of cochlear hair cell stereociliary bundles J:142392
craniorachischisis J:142392
decreased cochlear outer hair cell number J:142392
increased cochlear hair cell number J:142392
inner ear hypoplasia J:142392
Fat4tm1.1Hmc/Fat4tm1.1Hmc
Vangl2Lp/Vangl2+
involves: 129P2/OlaHsd * A * FVB/N 		kidney cyst J:138247
Fzd1tm1.1Nat/Fzd1+
Vangl2Lp/Vangl2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ 		open neural tube J:165556
ventricular septal defect J:165556
Fzd1tm1.1Nat/Fzd1+
Fzd2tm1.1Nat/Fzd2+
Vangl2Lp/Vangl2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ 		open neural tube J:165556
ventricular septal defect J:165556
Fzd2tm1.1Nat/Fzd2+
Vangl2Lp/Vangl2+
involves: 129 * C57BL/6 * LPT/LeJ 		abnormal heart morphology J:189062
ventricular septal defect J:189062
Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Vangl2Lp/Vangl2+
involves: 129 * C57BL/6 * LPT/LeJ 		abnormal heart morphology J:189062
cleft palate J:189062
ventricular septal defect J:189062
Fzd2tm1.1Nat/Fzd2tm1.1Nat
Vangl2Lp/Vangl2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ 		abnormal cochlear hair cell morphology J:165556
abnormal cochlear hair cell number J:165556
abnormal orientation of outer hair cell stereociliary bundles J:165556
cleft palate J:165556
open neural tube J:165556
ventricular septal defect J:165556
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Vangl2Lp/Vangl2+
involves: 129 * C57BL/6 * LPT/LeJ 		abnormal heart morphology J:189062
cleft palate J:189062
ventricular septal defect J:189062
Grhl3ct/?
Vangl2Lp/Vangl2+
involves: A * GFF 		abnormal astrocyte morphology J:125330
abnormal motor capabilities/coordination/movement J:125330
abnormal spinal cord morphology J:125330
decreased fetal weight J:125330
meningomyelocele J:125330
Lrp6skax26/Lrp6+
Vangl2Lp/Vangl2+
involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J 		abnormal orientation of outer hair cell stereociliary bundles J:206979
curly tail J:206979
kinked tail J:206979
spina bifida J:206979
Prickle1tm1Nue/Prickle1+
Vangl2Lp/Vangl2+
involves: C57BL/6J * CBA * LPT/LeJ 		abnormal embryonic epiblast morphology J:151993
Ptk7chz/Ptk7+
Vangl2Lp/Vangl2+
involves: A * BALB/cAnN * C3H/HeH 		craniorachischisis J:163834
spina bifida J:163834
Rpl10aem2Mbar/Rpl10a+
Vangl2Lp/Vangl2+
involves: A * C57BL/6 		spina bifida J:328993
ScribCrc/Scrib+
Vangl2Lp/Vangl2+
C3H.Cg-Vangl2Lp ScribCrc 		abnormal abdominal wall morphology J:216413
abnormal developmental patterning J:216413
abnormal eyelid morphology J:216413
craniorachischisis J:216413
curly tail J:216413
exencephaly J:216413
prenatal lethality, incomplete penetrance J:216413
ScribCrc/Scrib+
Vangl2+/Vangl2Lp
involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR 		craniorachischisis J:72608
curly tail J:72608
spina bifida J:72608
Scribcrn2/Scrib+
Vangl2Lp/Vangl2+
involves: A/J * FVB/N 		craniorachischisis J:174027
curly tail J:174027
Sec24bY613X/Sec24b+
Vangl2Lp/Vangl2+
involves: A * C3H/He * C57BL/6 		lethality throughout fetal growth and development, incomplete penetrance J:158452
postnatal lethality, incomplete penetrance J:158452
spina bifida J:158452
Sestd1tm1.1Bnrc/Sestd1+
Vangl2Lp/Vangl2+
involves: 129S6/SvEvTac * A * C57BL/6NCr 		curly tail J:201925
Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc
Vangl2Lp/Vangl2+
involves: 129S6/SvEvTac * A * C57BL/6NCr 		abnormal reproductive system development J:201925
abnormal urinary system development J:201925
curly tail J:201925
short tail J:201925
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2+
Sfrp5tm1Aksh/Sfrp5tm1Aksh
Vangl2Lp/Vangl2+
involves: 129 * A * C57BL/6 * LPT/LeJ 		spina bifida J:135313
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Sfrp5tm1Aksh/Sfrp5+
Vangl2Lp/Vangl2+
involves: 129 * A * C57BL/6 * LPT/LeJ 		abnormal rostral-caudal body axis extension J:135313
abnormal somite development J:135313
craniorachischisis J:135313
open neural tube J:135313
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp5tm1Aksh/Sfrp5tm1Aksh
Vangl2Lp/Vangl2+
involves: 129 * A * C57BL/6 * LPT/LeJ 		spina bifida J:135313
Usp39em1Imat/Usp39+
Vangl2Lp/Vangl2Lp
involves: A * CD-1 		abnormal limb development J:324183
short rostral-caudal axis J:324183
Vangl1Gt(XL802)Byg/Vangl1+
Vangl2Lp/Vangl2+
involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ 		abnormal cochlea morphology J:132697
abnormal cochlear hair cell stereociliary bundle morphology J:132697
abnormal orientation of inner hair cell stereociliary bundles J:132697
abnormal orientation of outer hair cell stereociliary bundles J:132697
normal cardiovascular system phenotype J:132697
craniorachischisis J:132697
curly tail J:132697
perinatal lethality, incomplete penetrance J:132697
retroesophageal right subclavian artery J:132697
Vangl1Gt(XL802)Byg/Vangl1+
Vangl2ska17/Vangl2+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J 		no abnormal phenotype detected J:169664
Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg
Vangl2Lp/Vangl2+
involves: 129P2/OlaHsd * A 		abnormal cochlear inner hair cell morphology J:162640
abnormal cochlear outer hair cell morphology J:162640
female infertility J:162640
short tail J:162640
vagina atresia J:162640
Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg
Vangl2tm1.2Yy/Vangl2+
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal cochlear outer hair cell morphology J:162640
long tail J:162640
Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg
Vangl2tm1.2Yy/Vangl2tm1.2Yy
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal cochlear inner hair cell morphology J:162640
abnormal cochlear outer hair cell morphology J:162640
abnormal embryo turning J:162640
abnormal embryonic cilium location or orientation J:162640
abnormal motile primary cilium physiology J:162640
abnormal notochord morphology J:162640
abnormal prenatal body size J:162640
failure of heart looping J:162640
heterotaxia J:162640
left pulmonary isomerism J:162640
Vangl2Lp/Vangl2+
Ptk7Gt(Betageo)1Matl/Ptk7+
involves: 129P2/Ola * C57BL/6 * LPT/LeJ 		normal hearing/vestibular/ear phenotype J:91298
spina bifida J:91298
Vangl2Lp/Vangl2+
MkksGt(OST367255)Lex/Mkks+
involves: 129S5/SvEvBrd * C57BL/6J * LPT/LeJ 		abnormal orientation of outer hair cell stereociliary bundles J:102697
abnormal outer hair cell stereociliary bundle morphology J:102697
embryonic lethality during organogenesis, complete penetrance J:102697
Vangl2Lp/Vangl2Lp
Tg(Dvl2/EGFP)2Awb/?
involves: LPT/LeJ 		abnormal organ of Corti morphology J:100861
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory