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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sirt1
sirtuin 1
MGI:2135607
158 phenotypes from 14 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+
Tg(Agrp-cre)1Gsb/0
involves: 129 * C57BL/6J * FVB/N 		normal adipose tissue phenotype J:209418
normal behavior/neurological phenotype J:209418
decreased food intake J:209418
decreased susceptibility to age related obesity J:209418
normal growth/size/body region phenotype J:209418
normal homeostasis/metabolism phenotype J:209418
increased body weight J:209418
increased food intake J:209418
increased response to leptin J:209418
Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+
Tg(Pomc1-cre)16Lowl/0
involves: 129 * C57BL/6J * FVB/N 		normal behavior/neurological phenotype J:209418
decreased circulating thyroxine level J:209418
decreased epididymal fat pad weight J:209418
decreased locomotor activity J:209418
decreased susceptibility to age related obesity J:209418
decreased susceptibility to induced hypothermia J:209418
decreased total body fat amount J:209418
normal growth/size/body region phenotype J:209418
normal homeostasis/metabolism phenotype J:209418
increased adipose tissue noradrenaline turnover J:209418
increased energy expenditure J:209418
increased oxygen consumption J:209418
increased response to leptin J:209418
Sirt1tm1.1Cxd/Sirt1+
either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N) 		exencephaly J:140089
Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N) 		abnormal cell cycle checkpoint function J:140089
abnormal cell death J:140089
abnormal chromosome morphology J:140089
abnormal DNA repair J:140089
abnormal DNA replication J:140089
abnormal head morphology J:140089
absent hindlimb buds J:140089
aneuploidy J:140089
decreased embryo size J:140089
decreased survivor rate J:140089
embryonic lethality during organogenesis, incomplete penetrance J:140089
increased cellular sensitivity to gamma-irradiation J:140089
increased cellular sensitivity to ultraviolet irradiation J:140089
increased mitotic index J:140089
lethality throughout fetal growth and development, incomplete penetrance J:140089
Sirt1tm1.1Vlcg/Sirt1tm1.1Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac 		no abnormal phenotype detected J:200671
Sirt1tm1.1Ygu/Sirt1tm1.1Ygu
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 		abnormal branching of the mammary ductal tree J:121948
abnormal mammary gland growth during pregnancy J:121948
abnormal mammary gland morphology J:121948
decreased body weight J:121948
hypolactation J:121948
neonatal lethality, incomplete penetrance J:121948
perinatal lethality, incomplete penetrance J:121948
postnatal growth retardation J:121948
postnatal lethality J:121948
normal reproductive system phenotype J:121948
Sirt1tm1.2Cxd/Sirt1tm1.2Cxd
Tg(Alb1-cre)1Dlr/?
involves: 129S6/SvEvTac * FVB/N 		hepatic steatosis J:179193
increased circulating free fatty acids level J:179193
increased circulating triglyceride level J:179193
increased liver triglyceride level J:179193
Sirt1tm1b(EUCOMM)Wtsi/Sirt1+
C57BL/6N-Sirt1tm1b(EUCOMM)Wtsi/H 		abnormal pelvic girdle bone morphology J:211773
abnormal scapula morphology J:211773
abnormal sinus arrhythmia J:211773
increased basophil cell number J:211773
Sirt1tm1b(EUCOMM)Wtsi/Sirt1tm1b(EUCOMM)Wtsi
C57BL/6N-Sirt1tm1b(EUCOMM)Wtsi/H 		abnormal iris morphology J:211773
abnormal maxilla morphology J:211773
abnormal snout morphology J:211773
abnormal tooth morphology J:211773
narrow eye opening J:211773
preweaning lethality, incomplete penetrance J:211773
Sirt1tm1Fwa/Sirt1tm1Fwa
involves: 129/Sv * 129S6/SvEvTac 		abnormal atrioventricular valve morphology J:85542
abnormal eye development J:85542
abnormal eye morphology J:85542
abnormal heart development J:85542
abnormal retina layer morphology J:85542
abnormal retina photoreceptor morphology J:85542
atrial septal defect J:85542
decreased body size J:85542
decreased embryo size J:85542
disorganized retina inner nuclear layer J:85542
disorganized retina outer nuclear layer J:85542
exencephaly J:85542
normal immune system phenotype J:85542
increased cellular sensitivity to ionizing radiation J:85542
microphthalmia J:85542
oligozoospermia J:85542
perinatal lethality, incomplete penetrance J:85542
postnatal lethality, incomplete penetrance J:85542
ventricular septal defect J:85542
Sirt1tm1Mcby/Sirt1tm1Mcby
129/Sv-Sirt1tm1Mcby 		abnormal adult Leydig cell differentiation J:146009
abnormal seminiferous tubule morphology J:146009
abnormal Sertoli cell development J:146009
abnormal spermatid morphology J:146009
abnormal spermatocyte morphology J:146009
arrest of male meiosis J:146009
arrest of spermatogenesis J:146009
decreased body size J:146009
decreased circulating follicle stimulating hormone level J:146009
decreased circulating luteinizing hormone level J:146009
decreased Leydig cell number J:146009
decreased testes secretion J:146009
increased male germ cell apoptosis J:146009
male infertility J:146009
multinucleated giant male germ cells J:146009
postnatal growth retardation J:146009
premature death J:146009
normal reproductive system phenotype J:146009
small seminiferous tubules J:146009
Sirt1tm1Mcby/Sirt1tm1Mcby
involves: 129 		abnormal digit development J:81010
decreased body weight J:81010
decreased CD8-positive, alpha-beta T cell number J:81010
decreased embryo size J:81010
exocrine pancreas atrophy J:81010
eyelids fail to open J:81010
heart right ventricle hypertrophy J:81010
interstitial pneumonia J:81010
lung inflammation J:81010
microphthalmia J:81010
perinatal lethality, incomplete penetrance J:81010
postnatal lethality, complete penetrance J:81010
pulmonary edema J:81010
short snout J:81010
Sirt1tm1Mcby/Sirt1tm1Mcby
involves: 129S1/Sv * 129X1/SvJ 		abnormal eyelid morphology J:241633
abnormal lacrimal gland morphology J:241633
abnormal palatal rugae morphology J:241633
abnormal salivary gland morphology J:241633
decreased body size J:160212, J:241633
decreased body weight J:160212
eyelids fail to open J:160212
female infertility J:160212, J:241633
hyperpnea J:241633
increased autoantibody level J:241633
lethargy J:241633
male infertility J:160212, J:241633
ocular hypotelorism J:241633
perinatal lethality J:241633
short snout J:241633
Sirt1tm1Mcby/Sirt1tm1Mcby
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal cellular respiration J:133127
abnormal digit development J:81010
abnormal estrous cycle J:81010
abnormal glucose tolerance J:133127
abnormal inguinal fat pad morphology J:133127
abnormal nursing J:81010
abnormal renal glomerulus morphology J:160869
abnormal seminiferous tubule epithelium morphology J:81010
abnormal sperm flagellum morphology J:81010
abnormal spermatid morphology J:81010
absent corpus luteum J:81010
absent estrous cycle J:81010
anovulation J:81010
decreased body weight J:81010
decreased brain weight J:133127
decreased CD8-positive, alpha-beta T cell number J:81010
decreased circulating thyroxine level J:133127
decreased embryo size J:81010
decreased locomotor activity J:133127
decreased testis weight J:81010
decreased urine osmolality J:160869
exocrine pancreas atrophy J:81010
eyelids fail to open J:81010
globozoospermia J:81010
glomerulonephritis J:160869
heart right ventricle hypertrophy J:81010
immotile sperm J:81010
increased anti-nuclear antigen antibody level J:160869
increased immunoglobulin level J:160869
increased insulin secretion J:133127
increased male germ cell apoptosis J:81010
increased oxygen consumption J:133127
increased urine antidiuretic hormone level J:160869
interstitial pneumonia J:81010
lung inflammation J:81010
male infertility J:81010
microphthalmia J:81010
oligozoospermia J:81010
perinatal lethality, incomplete penetrance J:81010
polydipsia J:160869
polyphagia J:133127
pulmonary edema J:81010
reduced female fertility J:81010
renal glomerular immunoglobulin deposits J:160869
short snout J:81010
slow postnatal weight gain J:133127
small ovary J:81010
teratozoospermia J:81010
thin uterus J:81010
Sirt1tm1Ygu/Sirt1tm1Ygu
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:121948
Sirt1tm2.1Fwa/Sirt1tm2.1Fwa
FVB.129S6-Sirt1tm2.1Fwa 		decreased body size J:162852
hypoactivity in response to feed restriction J:162852
normal mortality/aging J:162852
Sirt1tm2.1Fwa/Sirt1tm2.1Fwa
involves: 129/Sv * 129S6/SvEvTac 		abnormal eye morphology J:85542
Sirt1tm2Fwa/Sirt1tm2Fwa
involves: 129/Sv * 129S6/SvEvTac 		abnormal eye morphology J:85542
atrial septal defect J:85542
Sirt1tm3.1Mcby/Sirt1tm3.1Mcby
involves: 129/Sv * 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		abnormal lacrimal gland morphology J:241633
abnormal salivary gland morphology J:241633
ocular hypotelorism J:241633
reduced male fertility J:241633
short snout J:241633
Sirt1tm3Fwa/Sirt1tm3Fwa
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal circulating hormone level J:155802
abnormal pituitary gland physiology J:155802
decreased body length J:155802
decreased body weight J:155802
decreased circulating glucose level J:155802
decreased circulating growth hormone level J:155802
decreased circulating insulin level J:155802
decreased circulating insulin-like growth factor I level J:155802
decreased pituitary gland weight J:155802
hyperactivity J:155802
impaired glucose tolerance J:155802
increased circulating prolactin level J:155802
increased insulin sensitivity J:155802
small pituitary gland J:155802
Tg(Sirt1)ASrn/?
involves: C57BL/6 * CBA 		decreased susceptibility to diet-induced hepatic steatosis J:137868
improved glucose tolerance J:137868
increased energy expenditure J:137868
increased food intake J:137868
increased susceptibility to endotoxin shock J:137868
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory