Sirt1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sirt1
sirtuin 1
MGI:2135607

70 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Actb^{tm3.1(Sirt1)Npa}/Actb⁺ involves: 129/Sv * C57BL/6 * C57BL/6J	abnormal motor coordination/balance	J:160212
	normal behavior/neurological phenotype	J:160212
	decreased body weight	J:160212
	decreased circulating adiponectin level	J:160212
	decreased circulating cholesterol level	J:160212
	decreased circulating free fatty acids level	J:160212
	decreased circulating HDL cholesterol level	J:160212
	decreased circulating insulin level	J:160212
	decreased circulating LDL cholesterol level	J:160212
	decreased circulating leptin level	J:160212
	decreased epididymal fat pad weight	J:160212
	decreased fasting circulating glucose level	J:160212
	delayed fertility	J:160212
	normal homeostasis/metabolism phenotype	J:160212
	improved glucose tolerance	J:160212
	increased food intake	J:160212
	increased oxygen consumption	J:160212
	preweaning lethality, incomplete penetrance	J:160212
Actb^{tm3.1(Sirt1)Npa}/Actb⁺ Sirt1^tm1Mcby/Sirt1^tm1Mcby involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	normal growth/size/body region phenotype	J:160212
	normal reproductive system phenotype	J:160212
	normal vision/eye phenotype	J:160212
Actb^{tm3.1(Sirt1)Npa}/Actb^{tm3.1(Sirt1)Npa} involves: 129/Sv * C57BL/6 * C57BL/6J	preweaning lethality, complete penetrance	J:160212
Apc^Min/Apc⁺ Col1a1^{tm1(CAG-Sirt1)Dsin}/Col1a1⁺ involves: 129S4/SvJae * C57BL/6 * C57BL/6J	anemia	J:134301
	cachexia	J:134301
	increased gastrointestinal tumor incidence	J:134301
Apc^Min/Apc⁺ Col1a1^{tm1(CAG-Sirt1)Dsin}/Col1a1⁺ Tg(Vil1-cre)997Gum/0 involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL	decreased tumor incidence	J:134301
Ccar2^tm1Dac/Ccar2^tm1Dac Sirt1^tm1Ygu/Sirt1^tm1Ygu Tg(SERPINA1-cre)1Arge/0 involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J	decreased susceptibility to diet-induced obesity	J:228688
	normal growth/size/body region phenotype	J:228688
	normal homeostasis/metabolism phenotype	J:228688
Ccdc7a^{Tg(Prnp-Sirt1)10Imai}/? B6.Cg-Ccdc7a^{Tg(Prnp-Sirt1)10Imai}	abnormal brown adipose tissue physiology	J:203814
	abnormal neuron physiology	J:203814
	abnormal non-rapid eye movement sleep pattern	J:203814
	extended life span	J:203814
	hyperactivity	J:162852, J:203814
	hyperactivity elicited by feed restriction	J:162852
	increased body temperature	J:162852, J:203814
	increased energy expenditure	J:203814
	increased food intake	J:203814
	increased oxygen consumption	J:203814
	increased vertical activity	J:162852
	slow aging	J:203814
Sirt1^tm1.1Cxd/Sirt1⁺ Trp53^tm1Brd/Trp53⁺ either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)	abnormal tumor morphology	J:140089
	increased carcinoma incidence	J:140089
	increased lymphoma incidence	J:140089
	increased sarcoma incidence	J:140089
	increased teratoma incidence	J:140089
	increased tumor incidence	J:140089
Sirt1^tm1.1Cxd/Sirt1^tm1.1Cxd Trp53^tm1Brd/Trp53⁺ either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)	decreased survivor rate	J:140089
	embryonic lethality, incomplete penetrance	J:140089
	perinatal lethality, incomplete penetrance	J:140089
Sirt1^tm1.1Cxd/Sirt1^tm1.1Cxd Trp53^tm1Brd/Trp53^tm1Brd either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)	embryonic lethality, incomplete penetrance	J:140089
	lethality throughout fetal growth and development, incomplete penetrance	J:140089
	perinatal lethality, incomplete penetrance	J:140089
	postnatal lethality, complete penetrance	J:140089
Sirt1^tm2.1Mcby/Sirt1^tm2.1Mcby involves: 129S1/Sv * 129X1/SvJ	abnormal craniofacial morphology	J:241633
	abnormal eyelid morphology	J:241633
	abnormal lacrimal gland morphology	J:241633
	abnormal salivary gland morphology	J:241633
	decreased body size	J:241633
	hyperpnea	J:241633
	male infertility	J:241633
	perinatal lethality	J:241633
	postnatal lethality, incomplete penetrance	J:180628
Sirt1^tm2.1Mcby/Sirt1^tm2.1Mcby involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal energy expenditure	J:180628
	abnormal glucose homeostasis	J:180628
	abnormal glucose tolerance	J:180628
	abnormal spermatogenesis	J:180628
	decreased body size	J:180628
	decreased circulating insulin level	J:180628
	decreased respiratory quotient	J:180628
	decreased white adipose tissue amount	J:180628
	enlarged heart	J:180628
	enlarged pancreas	J:180628
	enlarged spleen	J:180628
	immotile sperm	J:180628
	increased brain size	J:180628
	increased food intake	J:180628
	increased oxygen consumption	J:180628
	male infertility	J:180628
	oligozoospermia	J:180628
	postnatal lethality, incomplete penetrance	J:180628
	short snout	J:180628

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