Pard3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pard3
par-3 family cell polarity regulator
MGI:2135608

25 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Krt14^tm1(cre)Wbm/Krt14⁺ Pard3^tm1Shoh/Pard3^tm1Shoh either: FVB.129-Pard3^tm1Shoh Krt14^tm1(cre)Wbm or (involves: 129P2/OlaHsd * 129S4/SvJae)	decreased incidence of tumors by chemical induction	J:192905
	decreased tumor growth/size	J:192905
	decreased tumor latency	J:192905
	increased incidence of tumors by chemical induction	J:192905
	increased metastatic potential	J:192905
	increased tumor growth/size	J:192905
	increased tumor latency	J:192905
	normal neoplasm	J:192905
Krt14^tm1(cre)Wbm/Krt14⁺ Pard3^tm1Shoh/Pard3^tm1Shoh involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J	abnormal epidermal melanocyte morphology	J:240961
	abnormal hair follicle melanocyte morphology	J:240961
	increased incidence of tumors by chemical induction	J:240961
	increased melanocyte number	J:240961
Krt14^tm1(cre)Wbm/Krt14⁺ Pard3^tm1Shoh/Pard3^tm1Shoh Tg(HIST1H2BB/EGFP)1Pa/0 involves: 129 * C57BL/6J	abnormal melanocyte morphology	J:240961
Pard3^tm1.1Shoh/Pard3^tm1.1Shoh involves: 129S4/SvJae * C57BL/6 * C57BL/6J	abnormal heart development	J:146415
	abnormal telencephalon development	J:146415
	edema	J:146415
	embryonic growth retardation	J:146415
	embryonic lethality during organogenesis, complete penetrance	J:146415
	heart atrium hypoplasia	J:146415
	increased heart atrium size	J:146415
	short tail	J:146415
	ventricular hypoplasia	J:146415
Pard3^{tm1b(KOMP)Wtsi}/Pard3⁺ C57BL/6N-Pard3^{tm1b(KOMP)Wtsi}/H	abnormal optic disk morphology	J:211773
	abnormal retina morphology	J:211773
	decreased basophil cell number	J:211773
Pard3^{tm1b(KOMP)Wtsi}/Pard3^{tm1b(KOMP)Wtsi} C57BL/6N-Pard3^{tm1b(KOMP)Wtsi}/H	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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