Crb1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Crb1
crumbs family member 1, photoreceptor morphogenesis associated
MGI:2136343

41 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Alpk1^em1Dlka/Alpk1⁺ Crb1^rd8/Crb1⁺ involves: C57BL/6J * C57BL/6N	normal vision/eye phenotype	J:344848
Alpk1^em1Dlka/Alpk1^em1Dlka Crb1^rd8/Crb1^rd8 involves: C57BL/6N	abnormal circulating chemokine level	J:344848
	normal growth/size/body region phenotype	J:344848
	normal immune system phenotype	J:344848
	increased circulating CXCL10 level	J:344848
Axin2^tm1Wbm/Axin2^tm1Wbm Crb1^rd8/? involves: 129P2/OlaHsd * C57BL/6	abnormal optic cup morphology	J:254591
	coloboma	J:254591
	small lens	J:254591
Crb1^em2Boc/Crb1^em2Boc Jak3^m1J/Jak3^m1J B6.Cg-Crb1^em2Boc Jak3^m1J/Boc	retina neovascularization	J:353326
Crb1^rd8+em1Boc/Crb1^rd8+em1Boc Jak3^m1J/Jak3^m1J B6.Cg-Crb1^rd8+em1Boc Jak3^m1J/Boc	small spleen	J:265859
	small thymus	J:265859
	normal vision/eye phenotype	J:265859
Crb1^rd8/Crb1⁺ rnv5/rnv5⁺ Not Specified	normal vision/eye phenotype	J:352529
Crb1^rd8/Crb1^rd8 Jak3^m1J/Jak3^m1J B6.Cg-Crb1^rd8 Jak3^m1J/BocJ	abnormal cone electrophysiology	J:265859
	abnormal electroretinogram waveform feature	J:265859
	abnormal eye electrophysiology	J:265859
	abnormal retina morphology	J:265859
	abnormal retina pigment epithelium morphology	J:265859
	abnormal retina pigmentation	J:265859
	abnormal retina vasculature morphology	J:265859
	abnormal rod electrophysiology	J:265859
	decreased spleen weight	J:265859
	retina neovascularization	J:265859
	retina spots	J:265859
	small spleen	J:265859
	small thymus	J:265859
Crb1^rd8/Crb1^rd8 Prkcq^tm1Litt/Prkcq^tm1Litt B6.129P2-Prkcq^tm1Litt	abnormal ocular fundus morphology	J:237977
	decreased eye pigmentation	J:237977
	retina degeneration	J:237977
	retina detachment	J:237977
Crb1^rd8/Crb1^rd8 rnv5/rnv5⁺ B6N.Cg-rnv5/BocJ	retina neovascularization	J:352529
Crb1^tm1Wij/Crb1⁺ Crb2^tm1.1Wij/Crb2^tm1.1Wij Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL	abnormal electroretinogram waveform feature	J:207895
	abnormal eye physiology	J:207895
	abnormal retina development	J:207895
	abnormal retina ganglion layer morphology	J:207895
	abnormal retina layer morphology	J:207895
	abnormal retina morphology	J:207895
	abnormal retina outer limiting membrane morphology	J:207895
	abnormal retina photoreceptor layer morphology	J:207895
	decreased retina apoptosis	J:207895
	increased retina apoptosis	J:207895
Crb1^tm1Wij/Crb1^tm1Wij Crb2^tm1.1Wij/Crb2^tm1.1Wij Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL	abnormal electroretinogram waveform feature	J:207895
	abnormal eye physiology	J:207895
	abnormal Muller cell morphology	J:207895
	abnormal retina bipolar cell morphology	J:207895
	abnormal retina layer morphology	J:207895
	abnormal retina morphology	J:207895
	abnormal retina outer limiting membrane morphology	J:207895
	abnormal retina photoreceptor layer morphology	J:207895
	abnormal retina progenitor cell morphology	J:207895
	decreased total retina thickness	J:207895
	disorganized retina layers	J:207895
	increased amacrine cell number	J:207895
	increased retina apoptosis	J:207895
	increased retina rod cell number	J:207895
	increased total retina thickness	J:207895
	retina degeneration	J:207895

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24