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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mrpl3
mitochondrial ribosomal protein L3
MGI:2137204
39 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mrpl3dcr/Mrpl3dcr
B6(Cg)-Mrpl3dcr/Dcr 		astrocytosis J:167846
brain vacuoles J:167846
cachexia J:167846
normal cardiovascular system phenotype J:167846
disheveled coat J:167846
hippocampal neuron degeneration J:289566
hunched posture J:167846
impaired learning J:289566
impaired spatial learning J:289566
increased susceptibility to ischemic brain injury J:167846
lethargy J:167846
nervous J:167846
neurodegeneration J:167846, J:289566
premature death J:167846
Mrpl3em1(IMPC)J/Mrpl3+
C57BL/6NJ-Mrpl3em1(IMPC)J/J 		increased circulating alkaline phosphatase level J:211773
increased circulating bilirubin level J:211773
increased hemoglobin content J:211773
increased mean corpuscular hemoglobin concentration J:211773
Mrpl3em1(IMPC)J/Mrpl3em1(IMPC)J
C57BL/6N-Mrpl3em1(IMPC)J/Mmucd 		abnormal cell cycle checkpoint function J:290315
abnormal egg cylinder morphology J:279207
abnormal embryonic epiblast morphology J:290315
abnormal mitochondrial ATP synthesis coupled electron transport J:290315
abnormal mitochondrial crista morphology J:290315
abnormal mitochondrial morphology J:290315
abnormal mitochondrial physiology J:290315
abnormal respiratory electron transport chain J:290315
absent allantois J:290315
absent head fold J:279207, J:290315
absent primitive node J:279207, J:290315
normal cellular phenotype J:290315
decreased cellular ATP level J:290315
decreased embryo size J:279207, J:290315
embryonic growth arrest J:279207, J:290315
embryonic growth retardation J:290315
embryonic lethality between implantation and placentation, complete penetrance J:279207, J:290315
failure of primitive streak formation J:279207, J:290315
failure to gastrulate J:279207, J:290315
Mrpl3em1(IMPC)J/Mrpl3em1(IMPC)J
C57BL/6NJ-Mrpl3em1(IMPC)J/J 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory