About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Twsg1
twisted gastrulation BMP signaling modulator 1
MGI:2137520
94 phenotypes from 6 alleles in 9 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Sox10-cre)1Wdr/0
Twsg1tm1Aptr/Twsg1tm1Aptr
involves: C57BL/6 * CBA 		abnormal frontonasal prominence morphology J:173627
abnormal telencephalon development J:173627
fused first pharyngeal arch J:173627
small first pharyngeal arch J:173627
Twsg1tm1.1Mboc/Twsg1tm1.1Mboc
129S/SvEv-Twsg1tm1.1Mboc 		abnormal craniofacial morphology J:88784
abnormal jaw morphology J:88784
abnormal vertebral arch morphology J:88784
decreased body size J:88784
decreased body weight J:88784
lethality at weaning, incomplete penetrance J:88784
neonatal lethality, incomplete penetrance J:88784
Twsg1tm1.1Mboc/Twsg1tm1.1Mboc
B6.129S7-Twsg1tm1.1Mboc 		abnormal cervical vertebrae morphology J:88784
abnormal craniofacial development J:88784
abnormal craniofacial morphology J:88784
abnormal head morphology J:88784
abnormal submandibular gland development J:144153
absent submandibular gland J:144153
agnathia J:88784
anophthalmia J:88784
cyclopia J:88784
decreased mouth size J:144153
fused first pharyngeal arch J:88784
lowered ear position J:144153
microphthalmia J:88784
perinatal lethality, incomplete penetrance J:88784
postnatal lethality, complete penetrance J:88784
single external naris J:88784
Twsg1tm1.1Mboc/Twsg1tm1.1Mboc
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N 		abnormal caudal vertebrae morphology J:88784
abnormal cervical vertebrae morphology J:88784
abnormal foregut morphology J:88784
abnormal gait J:88784
abnormal oropharynx morphology J:88784
abnormal thoracic vertebrae morphology J:88784
abnormal vertebrae morphology J:88784
abnormal vertebral arch morphology J:88784
abnormal vertebral lamina morphology J:88784
abnormal vertebral spinous process morphology J:88784
alobar holoprosencephaly J:88784
decreased body size J:88784
decreased body weight J:88784
decreased caudal vertebrae number J:88784
delayed bone ossification J:88784
hindlimb paralysis J:88784
kinked tail J:88784
premature death J:88784
short tail J:88784
Twsg1tm1Dgen/Twsg1tm1Dgen
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased body length J:101679
decreased body mass index J:101679
decreased body weight J:101679
kinked tail J:101679
weight loss J:101679
Twsg1tm1Ecan/Twsg1tm1Ecan
involves: 129 * C57BL/6 		abnormal skeleton development J:137597
abnormal skeleton morphology J:137597
abnormal tail morphology J:137597
decreased body size J:137597
decreased bone mineral content J:137597
decreased bone trabecula number J:137597
decreased bone volume J:137597
decreased circulating osteocalcin level J:137597
decreased trabecular bone volume J:137597
kinked tail J:137597
prenatal lethality, incomplete penetrance J:137597
short femur J:137597
short tail J:137597
Twsg1tm1Emdr/Twsg1tm1Emdr
involves: 129 * C57BL/6 * SJL 		prenatal lethality, incomplete penetrance J:141243
Twsg1tm1Emdr/Twsg1tm1Emdr
involves: 129X1/SvJ * C57BL/6 * SJL 		abnormal caudal vertebrae morphology J:90398
abnormal intervertebral disk development J:90398
abnormal tail morphology J:90398
abnormal vertebral arch development J:90398
decreased body weight J:90398
kinked tail J:90398
persistence of notochord tissue J:90398
short tail J:90398
Twsg1tm1Nosa/Twsg1tm1Nosa
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell differentiation J:82738
abnormal bone marrow cell morphology/development J:82738
abnormal gait J:82738
abnormal intervertebral disk morphology J:82738
abnormal intramembranous bone ossification J:82738
abnormal kidney development J:82738
abnormal limb bone morphology J:82738
abnormal long bone epiphyseal plate morphology J:82738
abnormal long bone epiphyseal plate proliferative zone J:82738
abnormal skeleton development J:82738
abnormal spleen development J:82738
abnormal thymus development J:82738
abnormal timing of postnatal eyelid opening J:82738
cachexia J:82738
decreased body size J:82738
decreased bone mineral density of femur J:82738
decreased bone mineral density of lumbar vertebrae J:82738
decreased double-positive T cell number J:82738
decreased erythrocyte cell number J:82738
decreased immature B cell number J:82738
decreased lymphocyte cell number J:82738
decreased pre-B cell number J:82738
decreased pro-B cell number J:82738
decreased spleen white pulp amount J:82738
decreased splenocyte number J:82738
decreased thymocyte number J:82738
decreased width of hypertrophic chondrocyte zone J:82738
delayed endochondral bone ossification J:82738
disproportionate dwarf J:82738
increased granulocyte number J:82738
increased monocyte cell number J:82738
increased single-positive T cell number J:82738
increased thymocyte apoptosis J:82738
internal hemorrhage J:82738
kinked tail J:82738
neonatal lethality, incomplete penetrance J:82738
postnatal growth retardation J:82738
premature death J:82738
pulmonary fibrosis J:82738
subarachnoid hemorrhage J:82738
thin neurocranium J:82738
thrombocytopenia J:82738
thymus atrophy J:82738
tremors J:82738
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory