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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Trp53bp2
transformation related protein 53 binding protein 2
MGI:2138319
76 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Trp53bp2tm2Xlu/Trp53bp2tm2Xlu
involves: 129P2/OlaHsd 		abnormal kidney physiology J:162396
Trp53bp2tm1b(EUCOMM)Hmgu/Trp53bp2+
C57BL/6N-Trp53bp2tm1b(EUCOMM)Hmgu/H 		hyperactivity J:211773
increased circulating aspartate transaminase level J:211773
increased hemoglobin content J:211773
Trp53bp2tm1b(EUCOMM)Hmgu/Trp53bp2tm1b(EUCOMM)Hmgu
C57BL/6N-Trp53bp2tm1b(EUCOMM)Hmgu/H 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Trp53bp2tm1Cdlo/Trp53bp2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cell cycle checkpoint function J:146764
abnormal T cell physiology J:146764
increased incidence of tumors by ionizing radiation induction J:146764
increased tumor incidence J:146764
Trp53bp2tm1Cdlo/Trp53bp2tm1Cdlo
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		embryonic lethality, complete penetrance J:146764
Trp53bp2tm1Xlu/Trp53bp2+
B6.129S6-Trp53bp2tm1Xlu 		abnormal retina morphology J:240594
abnormal spinal cord central canal morphology J:240594
cleft palate J:240594
ventricular septal defect J:240594
Trp53bp2tm1Xlu/Trp53bp2+
C.129S6-Trp53bp2tm1Xlu 		abnormal embryonic neuroepithelium morphology J:240594
abnormal lateral ventricle morphology J:240594
hemorrhage J:240594
ventricular septal defect J:240594
Trp53bp2tm1Xlu/Trp53bp2+
involves: 129S6/SvEvTac * C57BL/6J 		increased hemangiosarcoma incidence J:108701
increased incidence of tumors by ionizing radiation induction J:108701
increased lymphoma incidence J:108701
increased rhabdomyosarcoma incidence J:108701
increased squamous cell carcinoma incidence J:108701
increased T cell derived lymphoma incidence J:108701
increased tumor incidence J:108701
Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
B6.129S6-Trp53bp2tm1Xlu 		abnormal dorsal root ganglion morphology J:240594
abnormal heart position or orientation J:240594
abnormal neural tube morphology J:240594
abnormal retina morphology J:240594
abnormal sex gland morphology J:240594
abnormal trigeminal nerve morphology J:240594
abnormal urethra morphology J:240594
anophthalmia J:240594
cleft palate J:240594
coloboma J:240594
craniorachischisis J:240594
ductus venosus stenosis J:240594
intracranial hemorrhage J:240594
micrognathia J:240594
microphthalmia J:240594
narrow head J:240594
neonatal lethality, complete penetrance J:240594
spina bifida J:240594
umbilical vein stenosis J:240594
ventricular septal defect J:240594
wavy neural tube J:240594
Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
C.129S6-Trp53bp2tm1Xlu 		abnormal brain morphology J:162396
abnormal cerebral cortex morphology J:162396
abnormal choroid plexus morphology J:162396
abnormal cortical plate morphology J:162396
abnormal cortical ventricular zone morphology J:162396
abnormal embryonic neuroepithelial cell proliferation J:162396
abnormal embryonic neuroepithelium morphology J:162396
abnormal embryonic/fetal subventricular zone morphology J:162396
abnormal gait J:240594
abnormal heart position or orientation J:240594
abnormal lateral ventricle morphology J:240594
abnormal neural tube morphology J:240594
abnormal neuron differentiation J:162396
abnormal neuronal migration J:162396
abnormal olfactory bulb morphology J:240594
abnormal pineal gland morphology J:240594
abnormal retina morphology J:162396, J:240594
abnormal spinal cord central canal morphology J:240594
abnormal stratification in cerebral cortex J:162396
absent abducens nerve J:240594
absent pineal gland J:240594
cleft palate J:240594
disorganized retina layers J:162396
ductus venosus stenosis J:240594
enlarged brain ventricles J:240594
exencephaly J:240594
hydrocephaly J:162396
intracranial hemorrhage J:240594
intraventricular hemorrhage J:240594
normal mortality/aging J:162396
small thymus J:240594
ventricular septal defect J:240594
Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
involves: 129S6/SvEvTac * C57BL/6J 		abnormal brain morphology J:162396
abnormal cortical ventricular zone morphology J:162396
abnormal dorsal root ganglion morphology J:240594
abnormal embryonic neuroepithelial cell proliferation J:162396
abnormal embryonic/fetal subventricular zone morphology J:162396
abnormal neural tube morphology J:240594
abnormal neuronal precursor proliferation J:162396
abnormal retina morphology J:162396
abnormal retina outer nuclear layer morphology J:162396
abnormal retina photoreceptor layer morphology J:162396
abnormal retina progenitor cell morphology J:162396
abnormal sex gland morphology J:240594
abnormal trigeminal nerve morphology J:240594
abnormal urethra morphology J:240594
cleft palate J:240594
craniorachischisis J:240594
decreased body size J:108701, J:162396
dilated brain ventricle J:162396
domed cranium J:108701
exencephaly J:240594
hydrocephaly J:162396
increased embryonic neuroepithelial cell proliferation J:162396
increased neuron apoptosis J:162396
increased neuronal precursor cell number J:162396
micrognathia J:240594
narrow head J:240594
perinatal lethality, incomplete penetrance J:108701, J:162396
postnatal lethality, complete penetrance J:108701, J:162396
spina bifida J:240594
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory