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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mbd5
methyl-CpG binding domain protein 5
MGI:2138934
40 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mbd5Gt(Ayu21-B205)Imeg/Mbd5+
B6.Cg-Mbd5Gt(Ayu21-B205)Imeg 		abnormal learning/memory/conditioning J:212073
abnormal motor capabilities/coordination/movement J:212073
abnormal nasal bone morphology J:212073
abnormal neurite morphology J:212073
abnormal response to novel object J:212073
abnormal social investigation J:212073
normal behavior/neurological phenotype J:212073
decreased abdominal adipose tissue amount J:212073
decreased body size J:212073
decreased body weight J:212073
decreased grip strength J:212073
impaired coordination J:212073
increased grooming behavior J:212073
normal integument phenotype J:212073
Mbd5Gt(Ayu21-B205)Imeg/Mbd5Gt(Ayu21-B205)Imeg
B6.Cg-Mbd5Gt(Ayu21-B205)Imeg 		perinatal lethality, incomplete penetrance J:212073
Mbd5tm1.1Gxu/Mbd5tm1.1Gxu
Tg(Nes-cre)1Kln/0
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL 		decreased body size J:192212
decreased circulating growth hormone level J:192212
decreased circulating insulin-like growth factor I level J:192212
postnatal growth retardation J:192212
postnatal lethality, complete penetrance J:192212
Mbd5tm1.2Gxu/Mbd5tm1.2Gxu
involves: 129S2/SvPas * C57BL/6J 		abnormal glucose homeostasis J:192212
cachexia J:192212
decreased body size J:192212
decreased body weight J:192212
decreased circulating glucose level J:192212
decreased circulating insulin level J:192212
decreased circulating insulin-like growth factor I level J:192212
decreased gonadal fat pad weight J:192212
decreased growth hormone level J:192212
decreased liver weight J:192212
decreased subcutaneous adipose tissue amount J:192212
hypoglycemia J:192212
improved glucose tolerance J:192212
increased brain weight J:192212
increased insulin sensitivity J:192212
postnatal growth retardation J:192212
postnatal lethality, complete penetrance J:192212
small pituitary gland J:192212
Mbd5tm1b(EUCOMM)Wtsi/Mbd5+
C57BL/6N-Mbd5tm1b(EUCOMM)Wtsi/Ics 		abnormal lip morphology J:211773
decreased exploration in new environment J:211773
decreased leukocyte cell number J:211773
decreased locomotor activity J:211773
decreased lymphocyte cell number J:211773
decreased total retina thickness J:211773
short tibia J:211773
Mbd5tm1b(EUCOMM)Wtsi/Mbd5tm1b(EUCOMM)Wtsi
C57BL/6N-Mbd5tm1b(EUCOMM)Wtsi/Ics 		preweaning lethality, complete penetrance J:211773
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory