Hrh3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hrh3
histamine receptor H3
MGI:2139279

28 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hrh3^Eae8-r/? B10.S-H2^s/SgMcdJ	decreased susceptibility to experimental autoimmune encephalomyelitis	J:34892
Hrh3^Eae8-r/Hrh3^Eae8-r involves: B10.S/DvTe * SJL/J	decreased susceptibility to experimental autoimmune encephalomyelitis	J:49054
Hrh3^Eae8-s/? involves: B10.S * SJL/J	increased susceptibility to experimental autoimmune encephalomyelitis	J:49054
Hrh3^tm1.1Jhwa/Hrh3^tm1.1Jhwa involves: C57BL/6 * C57BL/6NTac	abnormal glucose homeostasis	J:174155
	decreased physiological sensitivity to xenobiotic	J:174155
	increased circulating glucose level	J:174155
Hrh3^tm1Kot/Hrh3^tm1Kot involves: 129X1/SvJ * C57BL/6N	abnormal energy expenditure	J:80824
	decreased core body temperature	J:80824
	decreased locomotor activity	J:80824
	decreased oxygen consumption	J:80824
	decreased response to leptin	J:80824
	increased circulating insulin level	J:80824
	increased circulating leptin level	J:80824
	increased susceptibility to weight gain	J:80824
	increased total body fat amount	J:80824
	insulin resistance	J:80824
	polyphagia	J:80824
Hrh3^tm1Twl/Hrh3^tm1Twl B6.129X1-Hrh3^tm1Twl	impaired blood-brain barrier function	J:122269
Hrh3^tm1Twl/Hrh3^tm1Twl B6.129X1-Hrh3^tm1Twl	increased susceptibility to experimental autoimmune encephalomyelitis	J:122269
Hrh3^tm1Twl/Hrh3^tm1Twl involves: 129P2/OlaHsd	abnormal cardiovascular system physiology	J:103897
	abnormal synaptic norepinephrine release	J:103897
	normal immune system phenotype	J:132140
Hrh3^tm1Twl/Hrh3^tm1Twl involves: 129P2/OlaHsd * C57BL/6J	abnormal anxiety-related response	J:79168
	abnormal circadian temperature homeostasis	J:79168
	abnormal hormone level	J:89633
	abnormal locomotor activation	J:79168
	abnormal nervous system physiology	J:79168
	abnormal spatial learning	J:89633
	decreased anxiety-related response	J:89633
	increased anxiety-related response	J:89633

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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