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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rtel1
regulator of telomere elongation helicase 1
MGI:2139369
30 phenotypes from 6 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL 		abnormal neural tube morphology J:130490
abnormal placenta morphology J:130490
embryonic lethality during organogenesis, complete penetrance J:130490
enlarged allantois J:130490
pericardial effusion J:130490
Rtel1tm1Hdin/Rtel1tm1Hdin
involves: 129S1/Sv * 129X1/SvJ 		decreased DNA replication J:202812
Rtel1tm1Hdin/Rtel1tm1Hdin
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		no abnormal phenotype detected J:130490
Rtel1tm1Pml/Rtel1tm1Pml
involves: 129S1/Sv * 129X1/SvJ 		abnormal cell differentiation J:91351
abnormal cephalic neural fold morphology J:91351
abnormal dermomyotome development J:91351
abnormal head paraxial mesoderm morphology J:91351
abnormal heart ventricle morphology J:91351
abnormal myotome development J:91351
abnormal neural crest cell morphology J:91351
abnormal neural tube morphology J:91351
abnormal placenta vasculature J:91351
decreased embryo size J:91351
decreased trophoblast giant cell number J:91351
embryonic growth retardation J:91351
embryonic lethality during organogenesis, complete penetrance J:91351
enlarged floor plate J:91351
failure of chorioallantoic fusion J:91351
hematoma J:91351
hemopericardium J:91351
incomplete rostral neuropore closure J:91351
small allantois J:91351
small ectoplacental cone J:91351
Rtel1tm2.1Hdin/Rtel1tm2.1Hdin
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cell physiology J:202812
abnormal mitosis J:202812
abnormal telomere morphology J:202812
normal cellular phenotype J:202812
decreased DNA replication J:202812
early cellular replicative senescence J:202812
Rtel1tm2.1Pml/Rtel1tm2.1Pml
129.129P2(B6)-Rtel1tm2.1Pml 		no abnormal phenotype detected J:197762
Rtel1tm3.1Hdin/Rtel1tm3.1Hdin
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal cellular phenotype J:202812
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory