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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Usp53
ubiquitin specific peptidase 53
MGI:2139607
29 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Usp53em1(IMPC)Tcp/Usp53em1(IMPC)Tcp
C57BL/6N-Usp53em1(IMPC)Tcp/Tcp 		abnormal auditory brainstem response J:211773
abnormal coat/ hair morphology J:211773
abnormal startle reflex J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased prepulse inhibition J:211773
decreased startle reflex J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating bilirubin level J:211773
increased circulating cholesterol level J:211773
increased circulating total protein level J:211773
prolonged PR interval J:211773
Usp53mbo/Usp53+
involves: BALB/cByJ * C57BL/6J 		normal hearing/vestibular/ear phenotype J:227841
increased susceptibility to noise-induced hearing loss J:227841
Usp53mbo/Usp53mbo
involves: BALB/cByJ * C57BL/6J 		abnormal cochlear outer hair cell morphology J:227841
abnormal orientation of outer hair cell stereociliary bundles J:227841
absent distortion product otoacoustic emissions J:227841
normal behavior/neurological phenotype J:227841
cochlear ganglion degeneration J:227841
cochlear hair cell degeneration J:227841
cochlear inner hair cell degeneration J:227841
cochlear outer hair cell degeneration J:227841
deafness J:227841
decreased endocochlear potential J:227841
Deiters cell degeneration J:227841
fused outer hair cell stereocilia J:227841
increased or absent threshold for auditory brainstem response J:227841
nonsyndromic hearing loss J:227841
organ of Corti degeneration J:227841
Usp53mbo/Usp53mbo
involves: C57BL/6J 		decreased startle reflex J:119820
increased or absent threshold for auditory brainstem response J:119820
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory