Pcsk9 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pcsk9
proprotein convertase subtilisin/kexin type 9
MGI:2140260

14 phenotypes from 7 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pcsk9^m1Bms/Pcsk9⁺ B6.Cg-Pcsk9^m1Bms	decreased circulating LDL cholesterol level	J:200728
Pcsk9^m1Bms/Pcsk9^m1Bms B6.Cg-Pcsk9^m1Bms	decreased circulating LDL cholesterol level	J:200728
Pcsk9^m1Bms/Pcsk9^m1Bms B6.Cg-Pcsk9^m1Bms	increased bile salt level	J:200728
Pcsk9^tm1.1Prat/Pcsk9^tm1.1Prat Speer6-ps1^{Tg(Alb-cre)21Mgn}/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	decreased circulating cholesterol level	J:169834
	decreased circulating HDL cholesterol level	J:169834
	decreased circulating LDL cholesterol level	J:169834
Pcsk9^tm1.2Prat/Pcsk9^tm1.2Prat involves: 129S1/Sv * 129X1/SvJ	abnormal cholesterol homeostasis	J:169834
	abnormal liver regeneration	J:169834
	decreased circulating cholesterol level	J:169834
	decreased circulating HDL cholesterol level	J:169834
	decreased circulating LDL cholesterol level	J:169834
	impaired liver regeneration	J:169834
Pcsk9^tm1Jdh/Pcsk9^tm1Jdh involves: 129S6/SvEvTac	decreased circulating cholesterol level	J:97836
	decreased circulating HDL cholesterol level	J:97836
	decreased circulating LDL cholesterol level	J:97836
Pcsk9^{tm2b(EUCOMM)Hmgu}/Pcsk9^{tm2b(EUCOMM)Hmgu} C57BL/6N-Pcsk9^{tm2b(EUCOMM)Hmgu}/Ieg	decreased circulating cholesterol level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating amylase level	J:211773
	increased circulating lipase level	J:211773
Tg(Apoe-Pcsk9)#Prat/? involves: C3H * C57BL/6	increased circulating cholesterol level	J:169834
	increased circulating HDL cholesterol level	J:169834
	increased circulating LDL cholesterol level	J:169834
Tg(Apoe-Pcsk9H229A)#Prat/? involves: C3H C57BL/6	normal homeostasis/metabolism phenotype	J:169834

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24