Ric8a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ric8a
RIC8 guanine nucleotide exchange factor A
MGI:2141866

22 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ric8a^tm1.1Zhua/Ric8a^tm1.1Zhua Tg(GFAP-cre)25Mes/0 involves: FVB/N	abnormal basement membrane morphology	J:191222
	abnormal Bergmann glial cell morphology	J:191222
	abnormal cerebellar foliation	J:191222
	abnormal cerebellar granule cell migration	J:191222
	abnormal cerebellum development	J:191222
	abnormal cerebellum lobule morphology	J:191222
	abnormal cerebellum morphology	J:191222
	absent cerebellum fissure	J:191222
	ataxia	J:191222
	ectopic cerebellar granule cells	J:191222
	ectopic Purkinje cell	J:191222
	enlarged cerebellum	J:191222
Ric8a^tm1.1Zhua/Ric8a^tm1.1Zhua Tg(Nes-cre)1Kln/0 involves: C57BL/6 * SJL	abnormal basement membrane morphology	J:191222
	abnormal Bergmann glial cell morphology	J:191222
	abnormal cerebellar foliation	J:191222
	abnormal cerebellum development	J:191222
	abnormal cerebellum lobule morphology	J:191222
	neonatal lethality, complete penetrance	J:191222
Ric8a^tm1Aks/Ric8a⁺ B6.129P2-Ric8a^tm1Aks	abnormal spatial learning	J:115754
Ric8a^tm1Aks/Ric8a⁺ B6.129P2-Ric8a^tm1Aks	increased anxiety-related response	J:115754
Ric8a^tm1Aks/Ric8a^tm1.1Zhua Tg(Atoh1-cre/Esr1)14Fsh/0 involves: 129P2/OlaHsd FVB/N	normal nervous system phenotype	J:191222
Ric8a^tm1Aks/Ric8a^tm1Aks B6.129P2-Ric8a^tm1Aks	embryonic lethality between implantation and somite formation, complete penetrance	J:115754
Ric8a^{tm1b(KOMP)Wtsi}/Ric8a⁺ C57BL/6N-Ric8a^{tm1b(KOMP)Wtsi}/J	impaired pupillary reflex	J:211773
	increased total body fat amount	J:211773
	persistence of hyaloid vascular system	J:211773
Ric8a^{tm1b(KOMP)Wtsi}/Ric8a^{tm1b(KOMP)Wtsi} C57BL/6N-Ric8a^{tm1b(KOMP)Wtsi}/J	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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