Nlrp6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nlrp6
NLR family, pyrin domain containing 6
MGI:2141990

33 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nlrp6^tm1Flv/Nlrp6^tm1Flv B6.Cg-Nlrp6^tm1Flv	abnormal gut flora balance	J:173245
	abnormal large intestine crypts of Lieberkuhn morphology	J:173245
	decreased circulating interleukin-18 level	J:173245
	decreased interleukin-18 secretion	J:173245
	diarrhea	J:243487
	enlarged Peyer's patches	J:173245
	increased B cell number	J:173245
	increased IgA level	J:173245
	increased IgG2c level	J:173245
	increased leukocyte cell number	J:173245
	increased susceptibility to induced colitis	J:173245
	increased susceptibility to Riboviria infection induced morbidity/mortality	J:243487
	increased susceptibility to xenobiotic induced morbidity/mortality	J:173245
Nlrp6^tm1Macha/Nlrp6^tm1Macha involves: 129S5/SvEvBrd * C57BL/6J	abnormal enterocyte proliferation	J:173352
	abnormal intestinal mucosa morphology	J:173352
	abnormal intestine physiology	J:173352
	decreased colon length	J:173352
	hunched posture	J:173352
	impaired wound healing	J:173352
	increased gastrointestinal tumor incidence	J:173352
	increased incidence of tumors by chemical induction	J:173352
	increased susceptibility to induced colitis	J:173352
	increased susceptibility to weight loss	J:173352
	increased susceptibility to xenobiotic induced morbidity/mortality	J:173352
	intestinal edema	J:173352
	intestinal ulcer	J:173352
	rectal hemorrhage	J:173352
Nlrp6^tm1Opaz/Nlrp6^tm1Opaz B6.Cg-Nlrp6^tm1Opaz	abnormal associative learning	J:220441
	normal behavior/neurological phenotype	J:220441
	decreased anxiety-related response	J:220441
	decreased systemic arterial systolic blood pressure	J:220441
	decreased urine osmolality	J:220441
	enhanced spatial learning	J:220441
	impaired spatial learning	J:220441
	increased urine flow rate	J:220441

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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