Ano1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ano1
anoctamin 1, calcium activated chloride channel
MGI:2142149

32 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ano1^tm1.1Cahb/Ano1^tm1.1Cahb Tg(Myh11-icre/ERT2)1Soff/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal blood vessel physiology	J:207993
	abnormal pericyte morphology	J:207993
	abnormal systemic arterial blood pressure	J:207993
	abnormal vascular smooth muscle morphology	J:207993
	normal cardiovascular system phenotype	J:207993
	decreased mean systemic arterial blood pressure	J:207993
	decreased vasoconstriction	J:207993
	normal homeostasis/metabolism phenotype	J:207993
Ano1^tm1.1Jwo/Ano1^tm1.1Jwo Avil^tm2(cre)Fawa/Avil⁺ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal sensory neuron morphology	J:191353
	normal behavior/neurological phenotype	J:191353
	increased thermal nociceptive threshold	J:191353
	normal integument phenotype	J:191353
Ano1^tm1.2Cahb/Ano1^tm1.2Cahb involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	abnormal tracheal cartilage morphology	J:207993
	postnatal lethality, complete penetrance	J:207993
Ano1^tm1Bdh/Ano1^tm1Bdh involves: 129S1/Sv	abnormal bronchial cartilage morphology	J:138613
	abnormal trachea morphology	J:138613
	abnormal tracheal cartilage morphology	J:138613
	abnormal tracheal ciliated epithelium morphology	J:138613
	abnormal tracheal smooth muscle morphology	J:138613
	aerophagia	J:138613
	cyanosis	J:138613
	decreased body weight	J:138613
	postnatal lethality, complete penetrance	J:138613
	slow postnatal weight gain	J:138613
Ano1^tm1Jrr/Ano1^tm1Jrr involves: 129S6/SvEvTac	abnormal renal tubule epithelium morphology	J:210158
Ano1^tm1Jrr/Ano1^tm1Jrr involves: 129S6/SvEvTac	increased urine protein level	J:210158
Ano1^tm2Jrr/Ano1^tm2Jrr Tg(Cdh16-cre)91Igr/0 involves: 129S6/SvEvTac * ICR	abnormal renal tubule epithelium morphology	J:210158
	albuminuria	J:210158
	decreased urine chloride ion level	J:210158
	decreased urine potassium level	J:210158
	decreased urine sodium level	J:210158
	increased circulating aldosterone level	J:210158
	increased circulating renin level	J:210158
	increased urine protein level	J:210158
Ano1^tm2Jrr/Ano1^tm2Jrr Tg(NPHS2-cre)295Lbh/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	normal renal/urinary system phenotype	J:210158
Ano1^tm2Jrr/Ano1^tm2Jrr Tg(Vil1-cre)997Gum/0 involves: 129S7/SvEvBrd * C57BL/6 * SJL	decreased intestinal epithelial chloride transmembrane transport	J:260534

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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