Lrrk1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lrrk1
leucine-rich repeat kinase 1
MGI:2142227

62 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lrrk1^m1Btlr/Lrrk1^m1Btlr C57BL/6J-Lrrk1^m1Btlr/Btlr	increased bone mineral density	J:309727
	short femur	J:309727
	short tibia	J:309727
	small pubis	J:309727
Lrrk1^M2Btlr/Lrrk1⁺ C57BL/6J-Lrrk1^m2Btlr/Btlr	short femur	J:309727
	short tibia	J:309727
	normal skeleton phenotype	J:309727
Lrrk1^tm1.1Mjff/Lrrk1^tm1.1Mjff C57BL/6-Lrrk1^tm1.1Mjff	preweaning lethality, incomplete penetrance	J:184821
Lrrk1^tm1.1Smo/Lrrk1^tm1.1Smo involves: 129S/Sv	abnormal bone marrow cavity morphology	J:208677
	abnormal bone mineralization	J:208677
	abnormal facial morphology	J:208677
	abnormal long bone metaphysis morphology	J:208677
	abnormal long bone morphology	J:208677
	abnormal osteoclast physiology	J:208677
	abnormal trabecular bone morphology	J:208677
	normal craniofacial phenotype	J:208677
	decreased body height	J:208677
	decreased bone resorption	J:208677
	decreased circulating alkaline phosphatase level	J:208677
	decreased susceptibility to osteoporosis	J:208677
	normal homeostasis/metabolism phenotype	J:208677
	increased bone mineral density	J:208677
	increased bone trabecula number	J:208677
	increased compact bone thickness	J:208677
	increased osteoclast cell number	J:208677
	increased trabecular bone thickness	J:208677
	increased trabecular bone volume	J:208677
	osteopetrosis	J:208677
	osteosclerosis	J:208677
	short femur	J:208677
	short tibia	J:208677
	normal skeleton phenotype	J:208677
Lrrk1^{tm1b(KOMP)Wtsi}/Lrrk1^{tm1b(KOMP)Wtsi} C57BL/6N-Lrrk1^{tm1b(KOMP)Wtsi}/H	abnormal clavicle morphology	J:211773
	abnormal eyelid morphology	J:211773
	abnormal femur morphology	J:211773
	abnormal fibula morphology	J:211773
	abnormal gait	J:211773
	abnormal humerus morphology	J:211773
	abnormal joint morphology	J:211773
	abnormal locomotor behavior	J:211773
	abnormal mandible morphology	J:211773
	abnormal maxilla morphology	J:211773
	abnormal pelvic girdle bone morphology	J:211773
	abnormal radius morphology	J:211773
	abnormal rib morphology	J:211773
	abnormal snout morphology	J:211773
	abnormal tibia morphology	J:211773
	abnormal tooth morphology	J:211773
	abnormal ulna morphology	J:211773
	abnormal vertebrae morphology	J:211773
	abnormal zygomatic bone morphology	J:211773
	absent teeth	J:211773
	decreased circulating alkaline phosphatase level	J:211773
	decreased eosinophil cell number	J:211773
	decreased lean body mass	J:211773
	decreased leukocyte cell number	J:211773
	decreased lymphocyte cell number	J:211773
	increased bone mineral content	J:211773
	increased bone mineral density	J:211773
	increased circulating aspartate transaminase level	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating creatine kinase level	J:211773
	increased circulating HDL cholesterol level	J:211773
	increased circulating iron level	J:211773
	increased circulating phosphate level	J:211773
	increased neutrophil cell number	J:211773
	increased red blood cell distribution width	J:211773
	increased spleen weight	J:211773
	increased total body fat amount	J:211773
	short tibia	J:211773
	thrombocytopenia	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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