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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fig4
FIG4 phosphoinositide 5-phosphatase
MGI:2143585
55 phenotypes from 6 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fig4plt1/Fig4plt1
B6.Cg-Fig4plt1 		abnormal heart atrium morphology J:190368
Fig4plt1/Fig4plt1
involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL 		abnormal brain morphology J:173446
abnormal myelin sheath morphology J:173446
abnormal sciatic nerve morphology J:173446
astrocytosis J:173446
decreased nerve conduction velocity J:173446
diluted coat color J:173446
hypopigmentation J:173446
neurodegeneration J:173446
neuron degeneration J:173446
premature death J:173446
spongiform encephalopathy J:173446
Fig4plt1/Fig4plt1
involves: 129P2/OlaHsd * C3H * C57BL/6 * CAST/Ei * SJL 		abnormal action potential J:122737
abnormal gait J:122737
abnormal hair follicle morphology J:122737
abnormal limb posture J:122737
abnormal melanosome morphology J:122737
abnormal motor capabilities/coordination/movement J:185989
abnormal motor neuron morphology J:122737
abnormal nerve conduction J:122737, J:185989
abnormal nervous system morphology J:185989
abnormal sciatic nerve morphology J:122737
astrocytosis J:185989
decreased body size J:122737
decreased body weight J:122737
decreased hair follicle number J:122737
demyelination J:185989
diluted coat color J:122737, J:185989
impaired coordination J:122737
muscle weakness J:122737
neuron degeneration J:122737
premature death J:122737, J:185989
spleen hypoplasia J:122737
spongiform encephalopathy J:185989
tremors J:122737, J:185989
Fig4plt1/Fig4plt1
involves: 129P2/OlaHsd * C3H * SJL 		abnormal bone marrow cell morphology/development J:203638
abnormal bone ossification J:203638
abnormal bone structure J:203638
abnormal compact bone morphology J:203638
abnormal craniofacial morphology J:203638
abnormal osteoblast morphology J:203638
abnormal skeleton morphology J:203638
abnormal trabecular bone morphology J:203638
decreased body weight J:203638
decreased bone trabecula number J:203638
decreased bone volume J:203638
decreased compact bone thickness J:203638
decreased length of long bones J:203638
decreased trabecular bone connectivity density J:203638
decreased trabecular bone volume J:203638
normal limbs/digits/tail phenotype J:203638
long incisors J:203638
postnatal growth retardation J:203638
small clavicle J:203638
Fig4plt1/Fig4plt1
Tg(ACTB-Fig4*I41T)705Mm/0
involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL 		abnormal brain morphology J:173446
astrocytosis J:173446
decreased nerve conduction velocity J:173446
diluted coat color J:173446
domed cranium J:173446
enlarged lateral ventricles J:173446
hydrocephaly J:173446
hypopigmentation J:173446
normal nervous system phenotype J:173446
neurodegeneration J:173446
premature death J:173446
spongiform encephalopathy J:173446
Fig4plt1/Fig4plt1
Tg(ACTB-Fig4*I41T)721Mm/0
involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL 		abnormal brain morphology J:173446
astrocytosis J:173446
decreased nerve conduction velocity J:173446
enlarged lateral ventricles J:173446
hydrocephaly J:173446
hypopigmentation J:173446
normal mortality/aging J:173446
normal nervous system phenotype J:173446
neurodegeneration J:173446
spongiform encephalopathy J:173446
Fig4plt1/Fig4plt1
Tg(Eno2-Fig4)#Mm/?
involves: 129P2/OlaHsd * C3H * C57BL/6 * CAST/Ei * SJL 		abnormal postnatal growth J:185989
normal nervous system phenotype J:185989
premature death J:185989
Fig4plt1/Fig4plt1
Tg(GFAP-Fig4)#Mm/?
involves: 129P2/OlaHsd * C3H * C57BL/6 * CAST/Ei * SJL 		abnormal motor capabilities/coordination/movement J:185989
abnormal postnatal growth J:185989
demyelination J:185989
normal nervous system phenotype J:185989
premature death J:185989
spongiform encephalopathy J:185989
tremors J:185989
Fig4tm1.1Mm/Fig4tm1.1Mm
Tg(Syn1-cre)671Jxm/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal motor capabilities/coordination/movement J:185989
astrocytosis J:185989
decreased body weight J:185989
normal integument phenotype J:185989
limb grasping J:185989
premature death J:185989
spongiform encephalopathy J:185989
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory