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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Traf3ip2
TRAF3 interacting protein 2
MGI:2143599
59 phenotypes from 5 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Traf3ip2adjm/Traf3ip2adjm
A.KOR-Traf3ip2adjm 		dermatitis J:162859
increased IgE level J:162859
Traf3ip2adjm/Traf3ip2adjm
AK.KOR-Traf3ip2adjm 		dermatitis J:162859
increased IgE level J:162859
Traf3ip2adjm/Traf3ip2adjm
B6.KOR-Traf3ip2adjm 		dermatitis J:162859
increased IgE level J:162859
Traf3ip2adjm/Traf3ip2adjm
C.KOR-Traf3ip2adjm 		dermatitis J:162859
increased IgE level J:162859
Traf3ip2adjm/Traf3ip2adjm
KOR-Traf3ip2adjm 		dermatitis J:162859
female infertility J:162859
increased IgE level J:162859
increased pruritus J:162859
premature death J:162859
thick epidermis J:162859
Traf3ip2Gt(IST11484G7)Tigm/Traf3ip2Gt(IST11484G7)Tigm
involves: C57BL/6N 		normal immune system phenotype J:177650
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
B6.129-Traf3ip2tm1.1Lix 		abnormal glomerular capillary morphology J:187766
abnormal renal glomerulus morphology J:187766
abnormal transitional stage B cell morphology J:187766
enlarged cervical lymph nodes J:187766
enlarged spleen J:187766
normal immune system phenotype J:187766
increased anti-chromatin antibody level J:187766
increased anti-double stranded DNA antibody level J:187766
increased anti-histone antibody level J:187766
increased anti-nuclear antigen antibody level J:187766
increased autoantibody level J:187766
increased B cell number J:187766
increased IgG1 level J:187766
increased IgG2c level J:187766
increased IgG level J:187766
increased immature B cell number J:187766
increased marginal zone B cell number J:187766
increased mesangial cell number J:187766
increased spleen weight J:187766
lymph node hyperplasia J:187766
spleen hyperplasia J:187766
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
C.129-Traf3ip2tm1.1Lix 		abnormal exocrine gland morphology J:138560
blepharitis J:138560
dry eyes J:138560
enlarged submandibular lymph nodes J:138560
glomerulonephritis J:138560
increased autoantibody level J:138560
increased follicular B cell number J:138560
increased inflammatory response J:138560
increased marginal zone B cell number J:138560
increased submandibular gland size J:138560
increased transitional stage B cell number J:138560
kidney inflammation J:138560
lacrimal gland inflammation J:138560
parotid gland inflammation J:138560
premature death J:138560
renal glomerular immunoglobulin deposits J:138560
stomatitis J:138560
submandibular gland inflammation J:138560
xerostomia J:138560
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
involves: 129/Sv * BALB/c 		abnormal immune system morphology J:93923
abnormal immune system physiology J:93923
abnormal spleen B cell corona morphology J:93923
enlarged lymph nodes J:93923
enlarged spleen J:93923
increased anti-double stranded DNA antibody level J:93923
increased anti-histone antibody level J:93923
increased anti-single stranded DNA antibody level J:93923
increased autoantibody level J:93923
increased B cell number J:93923
increased dendritic cell number J:93923
increased IgE level J:93923
increased IgG level J:93923
increased immunoglobulin level J:93923
increased inflammatory response J:93923
lymphoid hyperplasia J:93923
respiratory system inflammation J:93923
Traf3ip2tm1Lix/Traf3ip2tm1.1Lix
Tg(CD19-cre/ERT2)1Cgn/0
involves: 129/Sv * BALB/c 		enlarged lymph nodes J:93923
enlarged spleen J:93923
increased B cell number J:93923
increased dendritic cell number J:93923
increased immunoglobulin level J:93923
Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
either: B6.129-Traf3ip2tm1Sbn or (involves: 129) or (involves: 129 * BALB/c) 		abnormal cytokine secretion J:144320
decreased interleukin-6 secretion J:144320
decreased susceptibility to autoimmune disorder J:144320
impaired eosinophil recruitment J:144320
impaired macrophage chemotaxis J:144320
impaired neutrophil recruitment J:144320
Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
involves: 129 * C57BL/6 		decreased inflammatory response J:191090
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory