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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Smg6
SMG6 nonsense mediated mRNA decay factor
MGI:2144117
15 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Smg6em1(IMPC)Mbp/Smg6+
C57BL/6NCrl-Smg6em1(IMPC)Mbp/Mmucd 		abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal startle reflex J:211773
enlarged spleen J:211773
scaly skin J:211773
Smg6em1(IMPC)Mbp/Smg6em1(IMPC)Mbp
C57BL/6NCrl-Smg6em1(IMPC)Mbp/Mmucd 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Smg6tm1.1Zqw/Smg6tm1.1Zqw
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S4/SvJae 		abnormal cell morphology J:222980
abnormal cell physiology J:222980
abnormal telomere morphology J:222980
normal cellular phenotype J:222980
Smg6tm1.2Zqw/Smg6tm1.2Zqw
involves: 129P2/OlaHsd * C57BL/6 * CBA 		decreased inner cell mass proliferation J:222980
embryonic growth retardation J:222980
embryonic lethality at implantation, incomplete penetrance J:222980
prenatal lethality, complete penetrance J:222980
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory