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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pld4
phospholipase D family member 4
MGI:2144765
40 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lyz2tm1(cre)Ifo/0
Pld4tm1.1Nemz/Pld4tm1.1Nemz
involves: 129 * 129P2/OlaHsd * C57BL/6J 		normal hematopoietic system phenotype J:281205
Pld4em1(IMPC)Mbp/Pld4em1(IMPC)Mbp
C57BL/6N-Pld4em1(IMPC)Mbp/MbpMmucd 		abnormal spleen morphology J:211773
cornea opacity J:211773
decreased circulating calcium level J:211773
enlarged spleen J:211773
eye hemorrhage J:211773
increased leukocyte cell number J:211773
increased lymphocyte cell number J:211773
increased monocyte cell number J:211773
increased spleen weight J:211773
Pld4mpc96H/Pld4mpc96H
involves: BALB/c * C3H/HeH * C57BL/6J 		decreased body size J:234901
Pld4thss/Pld4thss
BALB/cJ-Pld4thss/GrsrJ 		abnormal alpha-beta T cell morphology J:278304
abnormal immunoglobulin level J:278304
decreased body size J:171492
decreased body weight J:278304
enlarged lymph nodes J:278304
enlarged spleen J:278304
increased anti-nuclear antigen antibody level J:278304
increased IgA level J:278304
increased IgE level J:278304
increased IgG2b level J:278304
increased IgG3 level J:278304
increased IgG level J:278304
increased IgM level J:278304
increased macrophage cell number J:278304
increased marginal zone B cell number J:278304
increased plasma cell number J:278304
increased plasmacytoid dendritic cell number J:278304
increased spleen germinal center number J:278304
lymph node hyperplasia J:278304
normal mortality/aging J:278304
renal glomerular immunoglobulin deposits J:278304
sparse hair J:171492
spleen hyperplasia J:278304
Pld4tm1.1Nemz/Pld4tm1.1Nemz
Tg(Itgax-cre)1-1Reiz/0
involves: 129 * C57BL/6 * C57BL/6J * CBA 		abnormal peritoneal macrophage morphology J:281205
Pld4tm1.2Nemz/Pld4tm1.2Nemz
B6.129(Cg)-Pld4tm1.1Nemz 		abnormal leukocyte cell number J:281205
abnormal peritoneal macrophage morphology J:281205
decreased B-1 B cell number J:281205
decreased NK T cell number J:281205
enlarged spleen J:281205
normal immune system phenotype J:281205
increased circulating CXCL10 level J:281205
increased circulating interferon-gamma level J:281205
increased marginal zone B cell number J:281205
increased monocyte cell number J:281205
normal mortality/aging J:281205
thrombocytopenia J:281205
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory