Pld4 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pld4
phospholipase D family member 4
MGI:2144765

16 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ifng^tm1Ts/Ifng^tm1Ts Pld4^tm1.2Nemz/Pld4^tm1.2Nemz involves: 129 * 129S7/SvEvBrd * C57BL/6J * FVB/N	decreased NK T cell number	J:281205
	normal hematopoietic system phenotype	J:281205
	increased susceptibility to induced morbidity/mortality	J:281205
Pld3^em1Nemz/Pld3^em1Nemz Pld4^tm1.2Nemz/Pld4^tm1.2Nemz B6.Cg-Pld3^em1Nemz Pld4^tm1.1Nemz	abnormal circulating chemokine level	J:281205
	decreased birth body size	J:281205
	hemophagocytosis	J:281205
	hepatic steatosis	J:281205
	normal homeostasis/metabolism phenotype	J:281205
	increased circulating CXCL10 level	J:281205
	increased circulating ferritin level	J:281205
	increased circulating interferon-gamma level	J:281205
	increased circulating tumor necrosis factor level	J:281205
	liver inflammation	J:281205
	preweaning lethality, complete penetrance	J:281205
Pld4^tm1.2Nemz/Pld4^tm1.2Nemz Rag1^tm1Mom/Rag1^tm1Mom involves: 129 * 129S7/SvEvBrd * C57BL/6J * FVB/N	abnormal peritoneal macrophage morphology	J:281205
	decreased NK T cell number	J:281205
Pld4^tm1.2Nemz/Pld4^tm1.2Nemz Tlr9^M7Btlr/Tlr9^M7Btlr involves: 129 * C57BL/6J * FVB/N	normal hematopoietic system phenotype	J:281205
	normal homeostasis/metabolism phenotype	J:281205
	normal immune system phenotype	J:281205

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24