Pelo Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pelo
pelota mRNA surveillance and ribosome rescue factor
MGI:2145154

26 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pelo^tm1.1Slac/Pelo^tm1.1Slac involves: C57BL/6J * FVB/N	abnormal cerebellum morphology	J:306384
Pelo^tm1.1Slac/Pelo^tm1.1Slac involves: C57BL/6J * FVB/N	embryonic lethality between implantation and somite formation, complete penetrance	J:306384
Pelo^tm1Imad/Pelo^tm1Imad either: 129 or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	abnormal extraembryonic endoderm formation	J:228122
	abnormal extraembryonic tissue morphology	J:81781
	abnormal germ layer development	J:81781
	absent extraembryonic coelom	J:81781
	absent inner cell mass proliferation	J:81781
	aneuploidy	J:81781
	decreased embryo size	J:228122
	embryonic growth arrest	J:81781
	embryonic growth retardation	J:81781
	embryonic lethality between implantation and somite formation, complete penetrance	J:81781
	polyploidy	J:81781
Pelo^tm1Imad/Pelo^tm2Imad involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	no abnormal phenotype detected	J:228122
Pelo^tm1Slac/Pelo^tm1Slac En1^tm2(cre)Wrst/En1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal brain interneuron morphology	J:306384
	abnormal cerebellum external granule cell layer morphology	J:306384
	cerebellum hypoplasia	J:306384
	decreased inferior colliculus size	J:306384
	decreased Purkinje cell number	J:306384
	decreased superior colliculus size	J:306384
	increased neuron apoptosis	J:306384
	increased neuronal precursor proliferation	J:306384
	loss of GABAergic neurons	J:306384
Pelo^tm1Slac/Pelo^tm1Slac Tg(Atoh1-cre)1Bfri/0 involves: C57BL/6J * CBA	abnormal cerebellum anterior lobe morphology	J:306384
	abnormal cerebellum external granule cell layer morphology	J:306384
	decreased cerebellar granule cell number	J:306384
	increased neuronal precursor proliferation	J:306384
Pelo^tm1Slac/Pelo^tm1Slac Tg(Gabra6-cre)B1Lfr/0 involves: C57BL/6J * DBA/2	normal nervous system phenotype	J:306384
Pelo^tm2Imad/Pelo^tm2Imad Tg(EIIa-cre)C5379Lmgd/? involves: 129S1/Sv * 129X1/SvJ * FVB/N	embryonic lethality, complete penetrance	J:228122

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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