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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Espl1
extra spindle pole bodies 1, separase
MGI:2146156
34 phenotypes from 7 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Espl1Gt(XL058)Byg/Espl1+
B6.129P2-Espl1Gt(XL058)Byg 		decreased tumor incidence J:174926
Espl1Gt(XL058)Byg/Espl1Gt(XL058)Byg
B6.129P2-Espl1Gt(XL058)Byg 		embryonic lethality between implantation and somite formation J:174926
Espl1tm1.1Kna/Espl1tm1.1Kna
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal hepatocyte morphology J:107916
abnormal liver regeneration J:107916
decreased bone marrow cell number J:107916
Espl1tm1.1Tno/Espl1+
involves: 129S4/SvJae * C57BL/6J 		abnormal chromosome morphology J:107917
Espl1tm1.1Tno/Espl1tm1.2Tno
involves: 129S4/SvJae * C57BL/6J 		abnormal cell nucleus morphology J:107917
decreased cell proliferation J:107917
Espl1tm1.2Kna/Espl1tm1.2Kna
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality between implantation and somite formation, complete penetrance J:107916
Espl1tm1.2Tno/Espl1tm1.2Tno
involves: 129S4/SvJae * C57BL/6J 		abnormal blastocyst morphology J:107917
abnormal cell nucleus morphology J:107917
abnormal inner cell mass proliferation J:107917
embryonic lethality, complete penetrance J:107917
Espl1tm2Pzg/Espl1+
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd 		abnormal centrosome morphology J:131838
abnormal gonadal ridge morphology J:131838
abnormal male germ cell morphology J:131838
abnormal mitosis J:131838
abnormal spermatid morphology J:131838
abnormal spermatocyte morphology J:131838
abnormal spermatogenesis J:131838
abnormal spermatogonia morphology J:131838
absent primordial germ cells J:131838
aneuploidy J:131838
decreased primordial germ cell proliferation J:131838
female infertility J:131838
increased mitotic index J:131838
infertility J:131838
male infertility J:131838
small testis J:131838
Espl1tm2Pzg/Espl1tm2Pzg
involves: 129S7/SvEvBrd 		embryonic lethality during organogenesis J:131838
Tg(MMTV-Espl1)1Pati/0
involves: C57BL/6 		abnormal chromosome morphology J:216267
abnormal involution of the mammary gland J:216267
aneuploidy J:216267
chromosomal instability J:216267
increased mammary adenocarcinoma incidence J:216267
increased mammary gland tumor incidence in breeding females J:216267
mammary gland hyperplasia J:216267
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory