Espl1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Espl1
extra spindle pole bodies 1, separase
MGI:2146156

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Espl1^Gt(XL058)Byg/Espl1⁺ Trp53^tm1Tyj/Trp53⁺ B6.129-Trp53^tm1Tyj Espl1^Gt(XL058)Byg	increased carcinoma incidence	J:174926
Espl1^Gt(XL058)Byg/Espl1⁺ Trp53^tm1Tyj/Trp53^tm1Tyj B6.129-Trp53^tm1Tyj Espl1^Gt(XL058)Byg	abnormal bone marrow cell physiology	J:174926
	abnormal splenocyte morphology	J:174926
	abnormal tumor pathology	J:174926
	aneuploidy	J:174926
	increased carcinoma incidence	J:174926
	increased lymphoma incidence	J:174926
	increased metastatic potential	J:174926
	increased splenocyte proliferation	J:174926
	premature death	J:174926
Espl1^tm1.1Kna/Espl1^tm1.2Kna Wapl^tm1.1Jmpt/Wapl^tm1.2Jmpt Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL	abnormal mitosis	J:205429
Espl1^tm1.1Tno/Espl1⁺ Pttg1^tm1.1Tno/Pttg1^tm1.1Tno involves: 129S4/SvJae * C57BL/6J	decreased cell proliferation	J:107917
Espl1^tm1.2Kna/Espl1⁺ Pttg1^tm1.2Kna/Pttg1^tm1.2Kna involves: 129P2/OlaHsd * C57BL/6	abnormal cell death	J:107916
	abnormal cell nucleus morphology	J:107916
	abnormal mitosis	J:107916
	abnormal mitotic spindle morphology	J:107916
	abnormal neural tube morphology	J:107916
	abnormal somite development	J:107916
	decreased embryo size	J:107916
	embryonic lethality during organogenesis, complete penetrance	J:107916
Espl1^tm1.2Tno/Espl1⁺ Pttg1^tm1.1Tno/Pttg1^tm1.1Tno involves: 129S4/SvJae * C57BL/6J	embryonic growth retardation	J:107917
	embryonic lethality, complete penetrance	J:107917

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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